LABORATORY OF CHEMICAL BIOLOGY AND BIOPHYSICAL CHEMISTRY

 

 

Welcome to our group

Welcome at the website of the Joint Laboratory of Chemical Biology and Biophysical Chemistry operating at the Centre of New Technologies and the Division of Biophysics, Faculty of Physics, University of Warsaw. Our group is interested in the chemical synthesis, properties and applications of modified nucleotides and nucleic acids. Our research encompasses improving methods for the chemical synthesis of nucleotide analogs, designing new modified nucleotides as tools for molecular biology and conjugating nucleotides to labels, tags and new materials. One of our particular interests, is development of eukaryotic mRNA modifications, including cap analogs, with potential medicinal applications.

 

 

Enjoy our New Website!

Enjoy our New Website!

As of April 2022, we have refreshed the look of our website thanks to our partnership with Marcin Jemielity. We hope that you will enjoy the new look of our website.                      

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FNP Prize for Jacek

FNP Prize for Jacek

Jacek has been Awarded the 2021 Foundation for Polish Science Prize in chemistry and materials sciences for developing chemical modifications of mRNA as tools for therapeutic applications and studies on cellular processes.  

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Prof. Dr. hab. Jacek Jemielity

Centre of New Technologies

University of Warsaw

Laboratory of Chemical Biology

Dr. hab. Joanna Kowalska

Division of Biophysics

Faculty of Physics of University of Warsaw

Laboratory of Biophysical Chemistry

SELECTED PUBLICATIONS

Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation

By A. Mamot, P.J. Sikorski, A. Siekierska, P. de Witte, J. Kowalska, J. Jemielity;  Nucleic Acids Research 50, e3-e3

5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR

By M. R. Baranowski, M. Warminski, J. Jemielity, J. Kowalska;  Nucleic Acids Research 48, 8209-8224.

5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes

By B. A. Wojtczak, P. J. Sikorski, K. Fac-Dąbrowska, A. Nowicka, M. Warmiński, D. Kubacka, E. Nowak, M. Nowotny, J. Kowalska, J. Jemielity; Journal of the American Chemical Society 140, 5987-5999

Cellular delivery of dinucleotides by conjugation with small molecules: Targeting translation initiation for anticancer applications

By N Kleczewska, PJ Sikorski, Z Warminska, L Markiewicz, R Kasprzyk, N. Baran, K. Kwapiszewska, A. Karpinska, J. Michalski, R. Holyst, J. Kowalska, J. Jemielity; Chemical Science 12, 10242-10251.

The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells

By P. J. Sikorski, M. Warminski, D. Kubacka, T. Ratajczak, D. Nowis, J. Kowalska, J.Jemielity; Nucleic Acids Research 48, 1607-1626.

Azido-Functionalized 5ʹ-Cap Analogs for Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells

By Mamot A., Sikorski P. J., Warminski M., Kowalska J., Jemielity J; Angewandte Chemie International Edition 56, 15628–15632

TEAM LEADERS

Jacek Jemielity, Prof.

Jacek Jemielity, Prof.

j.jemielity@cent.uw.edu.pl

Joanna Kowalska, Ph.D., D.Sc.

Joanna Kowalska, Ph.D., D.Sc.

jkowalska@fuw.edu.pl

SENIOR SCIENTISTS

Marcin Warmiński, Ph.D.

Marcin Warmiński, Ph.D.

marcin.warminski@fuw.edu.pl

Paweł Sikorski, Ph.D.

Paweł Sikorski, Ph.D.

p.sikorski@cent.uw.edu.pl

LAB MANAGERS

Sebastian Chmieliński, M.Sc. Eng.

Sebastian Chmieliński, M.Sc. Eng.

Karolina Kaczmarska, M.Sc.

Karolina Kaczmarska, M.Sc.

POST-DOCS

Mikołaj Chromiński, Ph.D.

Mikołaj Chromiński, Ph.D.

Anaïs Depaix, Ph.D.

Anaïs Depaix, Ph.D.

Karolina Drążkowska, Ph.D.

Karolina Drążkowska, Ph.D.

Dr Małgorzata Wąsińska-Kalwa

Dr Małgorzata Wąsińska-Kalwa

Bartłomiej Fedorczyk, Ph.D.

Bartłomiej Fedorczyk, Ph.D.

PH. D. STUDENTS

Adam Mamot, M. Sc.

Adam Mamot, M. Sc.

Marcelina Bednarczyk, M. Sc.

Marcelina Bednarczyk, M. Sc.

Marek Baranowski, M. Sc.

Marek Baranowski, M. Sc.

Olga Perzanowska, M. Sc.

Olga Perzanowska, M. Sc.

Agnieszka Młynarska-Cieślak, M. Sc. Eng.

Agnieszka Młynarska-Cieślak, M. Sc. Eng.

Mateusz Kozarski, M. Sc.

Mateusz Kozarski, M. Sc.

Katarzyna Grab, M. Sc.

Katarzyna Grab, M. Sc.

Tomasz Śpiewla, M. Sc.

Tomasz Śpiewla, M. Sc.

Piotr Surynt, M. Sc.

Piotr Surynt, M. Sc.

Hai Van Nguyen, M. Sc.

Hai Van Nguyen, M. Sc.

Kamil Ziemkiewicz, M. Sc.

Kamil Ziemkiewicz, M. Sc.

UNDERGRADUATE STUDENTS

FORMER MEMBERS

Technician In the group Moved on to
Katarzyna Mokrzewska (Wnęk) 2010-2017 PRA Health Sciences
Michał Magda Lund University
Post-docs
Natalia Kleczewska 2017-2020 Imperial College London (Livingston group)
Dorota Kubacka 2015-2021 Celon Pharma
Łukasz Markiewicz 2019-2022 Medical University of Lodz
Tomasz Ratajczak 2017-2020 Polfa Warszawa
Mirosław Śmietański 2018-2022 Explorna Therapeutics
Błażej Wojtczak 2012-2021
Anna Wypijewska del Nogal 2012-2013 Max Planck Institute for Biophysical Chemistry
PhD Students
Malwina Strenkowska 2008-2016 Springer Nature
Małgorzata Żytek (Waszczuk) 2010-2016
Marcin Ziemniak 2008-2016 University of Warsaw (Faculty of Chemistry)
Renata Kasprzyk 2011-2021 University of Konstanz (Marx group)
Anna Wojtczak (Nowicka) 2010-2021
Sylwia Ciechanowicz (Walczak) 2011-2019
Dominika Strzelecka 2010-2021 Institut Européen de Chimie et Biologie (Gebelica group)
Przemysław Wanat 2009-2021 Oncoarendi Therapeutics
MSc Students
Sylwia Bednarek 2012-2017
Jakub Dąbrowski 2012-2016
Krystian Ubych 2009-2016
Maciej Majewski 2012-2016
Paulina Wysmołek 2013-2016
Kaja Fac 2011-2016
Monika Wanat (Nowakowska) 2010-2015
Paweł Dąbrowski-Tumański 2008-2014
Joanna Kasprzyk 2005-2012
Agnieszka Osówniak 2012-2016
Sylwia Szczepaniak 2006-2009
Anna M. Rydzik 2006-2009
Marta Kuliś 2006-2009
Marcin Kałek 2002-2005
Kinga Doniek
Sebastian Gołojuch
Radosław Wójcik
Jagoda Starek
Teodor Olejko
Teresa Piechowiak
Andrzej Kraszewski
Zofia Warmińska
Undergraduate Students
Małgorzata Domańska 2016-2017
Aleksandra Pompa 2013-2015
Radosław Piwowarski 2014-2015
Anna Dawid 2013-2014
Jakub M. Czarnecki 2008-2010
Julia Kamieńska
Paulina Jońca
Oktawia Wawrzyńska

 

Contact US

 

Address

Centre of New Technologies, University of Warsaw

Banacha 2C 02-097, Warsaw

Address 2

Division of Biophysics, Faculty of Physics of University of Warsaw

Ludwika Pasteura 5A 02-093, Warsaw