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[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Courses” _builder_version=”3.22″ custom_padding=”0px|0px|100px|0px” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” custom_padding=”0px|||||” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

SELECTED PUBLICATIONS<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Courses” _builder_version=”3.22″ custom_padding=”0px|0px|100px|8px||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.10.8″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_margin=”|||” custom_padding=”0px|0px|27px|0px” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo” url=”https:\/\/doi.org\/10.1021\/jacs.3c12629″ url_new_window=”on” image=”https:\/\/chembiobiochem.com\/wp-content\/uploads\/2024\/06\/images_large_ja3c12629_0012.jpeg” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|42px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

By M. Warminski, E. Trepkowska, M. Smietanski, P. J. Sikorski, M. R. Baranowski, M. Bednarczyk, H. Kedzierska, B. Majewski, A. Mamot, D. Papiernik, A. Popielec, R. A. Serwa, B. A. Shimanski, P. Sklepkiewicz, M. Sklucka, O. Sokolowska, T. Spiewla, D. Toczydlowska-Socha, Z. Warminska, K. Wolosewicz, J. Zuberek, J. S. Mugridge, D. Nowis, J. Golab, J. Jemielity, J. Kowalska; Journal of the American Chemical Society 146(12), 8149-8163<\/strong><\/a><\/span><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates. ” url=”https:\/\/www.nature.com\/articles\/s41557-023-01347-2″ url_new_window=”on” image=”https:\/\/chembiobiochem.com\/wp-content\/uploads\/2024\/01\/obraz_2024-01-07_194455927.png” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|42px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By H.-J. Zhang, M. Ociepa, M. Nassir, B. Zheng, S. A. Lewicki, V. Salmaso, H. Baburi, J. Nagel, S. Mirza, B. Bueschbell, H. Al-Hroub, O. Perzanowska, Z. Lin, M. A. Schmidt, M. D. Eastgate, K. A. Jacobson, C. E. M\u00fcller, J. Kowalska, J. Jemielity, P. S. Baran<\/span>
Nature Chemistry (2023), 1-10 <\/strong><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Ethylenediamine derivatives efficiently react with oxidized RNA 3\u2032 ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation” url=”https:\/\/academic.oup.com\/nar\/article\/50\/1\/e3\/6378437?searchresult=1″ url_new_window=”on” image=”https:\/\/oup.silverchair-cdn.com\/oup\/backfile\/Content_public\/Journal\/nar\/50\/1\/10.1093_nar_gkab867\/2\/m_gkab867fig6.jpeg?Expires=1649987578&Signature=EUMeifHXfgfpOLopsFrJvoZWQAHedq46EAHwCu-9mRycfhFSsEiDfrxaX-UC5TjkNn~-vlaqhMJnSih7CfPeVyqj9MhNz8mKitC-2Y82WSdrWoJYYbI8WMdc8uHK6WLjsDbqEmkTfqkMfMO7pSv~IhSVKi1ptswOEzylV39LtPiSq0fONkk9W300BaEJU4J5a0xtagchwksOAKj4k5piA68a6W235RxSRMTZVqYwE4L1N685zerGyogdd80~~TubDRLibPcphHrBnHgBs-oIUfwpIipQYvcciCbJUFUS-Q8IJa9QwWI5lt3EwG6vicAPVx1dXxp8Na~IHJFHMg5Rog__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|40px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By<\/span>\u00a0<\/span>A. Mamot, P.J. Sikorski, A. Siekierska, P. de Witte, J. Kowalska, J. Jemielity;\u00a0 Nucleic Acids Research 50, e3-e3<\/strong><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”5\u2032-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR” url=”https:\/\/academic.oup.com\/nar\/article\/50\/1\/e3\/6378437?searchresult=1″ url_new_window=”on” image=”https:\/\/oup.silverchair-cdn.com\/oup\/backfile\/Content_public\/Journal\/nar\/48\/15\/10.1093_nar_gkaa470\/1\/gkaa470fig5.jpeg?Expires=1650824323&Signature=Xz7v2unFAmQnf5y2cI80sVTA~RnwBk~eSqxxCblhy~fKmtdO7lA2zcRe1Gmk~w8KNnPx-vDBOJfDkh83phiCnvBcdiI6pwT056dSWukfFfMkbcwz39HpWGgETRe26S0hy39rzIqSsT6U5muxmHS~jQ08XTprmEqdABykgNoI1dj9MOop92O2JjwJk1sV~mTKXUb5~7Tzz3IQ3vTFV7l7E6BDJ268mhlTKK8Cyy3~O3eqCwcfFeu5X82awxjt3Pmle3uAhZkbSByyb3pRNNkHnpvvoMSPuGG3nGdGRYfDTxtmKkGDsbTbjgLVwSWXB4vXqrKsjaDGxUeaTScdbuirhg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|42px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By<\/span> M. R. Baranowski, M. Warminski, J. Jemielity, J. Kowalska;\u00a0 <\/span>Nucleic Acids Research 48, 8209-8224.<\/strong><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”5\u2032-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes” url=”https:\/\/academic.oup.com\/nar\/article\/50\/1\/e3\/6378437?searchresult=1″ url_new_window=”on” image=”https:\/\/pubs.acs.org\/na101\/home\/literatum\/publisher\/achs\/journals\/content\/jacsat\/2018\/jacsat.2018.140.issue-18\/jacs.8b02597\/20180503\/images\/medium\/ja-2018-02597d_0010.gif” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|42px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By<\/span> B. A. Wojtczak, P. J. Sikorski, K. Fac-D\u0105browska, A. Nowicka, M. Warmi\u0144ski, D. Kubacka, E. Nowak, M. Nowotny, J. Kowalska, J. Jemielity;<\/span> Journal of the American Chemical Society 140, 5987-5999<\/strong><\/p>\n

[\/et_pb_blurb][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_blurb title=”Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design” url=”https:\/\/doi.org\/10.1038\/s41467-025-61775-1″ url_new_window=”on” image=”https:\/\/chembiobiochem.com\/wp-content\/uploads\/2025\/08\/Circ-Nat-Comm.jpg” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|40px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By M. W\u0105sinska-Kalwa, A. Mamot, K. Czubak, K. Frankowska, A. A. Rajkiewicz, T. \u015apiewla, M Warmi\u0144ski, Zofia Pilch, M. Szulc-G\u0105siorowska, K. Siekan, A. Dziembowski, D. Nowis, J. Go\u0142\u0105b, J. Kowalska, J.Jemielity<\/span><\/span>
Nature Communications 16, 6455<\/strong><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Chemical Modifications of mRNA Ends for Therapeutic Applications.” url=”https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.accounts.3c00442″ url_new_window=”on” image=”https:\/\/chembiobiochem.com\/wp-content\/uploads\/2024\/01\/obraz_2024-01-07_194817165.png” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|40px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By M. Warminski, A. Mamot, A. Depaix, J. Kowalska, J. Jemielity;<\/span><\/span>
Accounts of Chemical Research 56, 2814-2826<\/strong><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Cellular delivery of dinucleotides by conjugation with small molecules: Targeting translation initiation for anticancer applications” url=”https:\/\/academic.oup.com\/nar\/article\/50\/1\/e3\/6378437?searchresult=1″ url_new_window=”on” image=”https:\/\/pubs.rsc.org\/en\/Image\/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1SC02143E&imageInfo.ImageIdentifier.Year=2021″ image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|40px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By N Kleczewska, PJ Sikorski, Z Warminska, L Markiewicz, R Kasprzyk, N. Baran, K. Kwapiszewska, A. Karpinska, J. Michalski, R. Holyst, J. Kowalska, J. Jemielity;<\/span><\/span> Chemical Science 12, 10242-10251.<\/strong><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5\u2032 cap modulates protein expression in living cells” url=”https:\/\/academic.oup.com\/nar\/article\/50\/1\/e3\/6378437?searchresult=1″ url_new_window=”on” image=”https:\/\/oup.silverchair-cdn.com\/oup\/backfile\/Content_public\/Journal\/nar\/48\/4\/10.1093_nar_gkaa032\/1\/m_gkaa032fig1.jpeg?Expires=1650366875&Signature=SWvs4Dd5CkQj3maYQF2YBloeeR1dNx~4cSENds2VfMvof~hoBivbdADgyQJk6xdKHLseeBO4e3-kEeK12l1xkipb~r8On6YmR3BWzTlKtYApzWv9bjQyghE7-~chMHKFt0nDJNCAu-h3dqD66gPQ35osPeKBuwvopyBC6L5fFR~fKz6FfHtDZx7i4ig8JI4yzChXZ3Sftl5gPjZHAnE5mQunSREGdMzlmP8PnoIMKDF7Jt-Ix~MWne1ffg-KYWz5jAVLAE6S8xt54MAhSwT7aaihlNJ1kxyLTIg-cByBdWmQ2opMCOGPuxn8KRGWrT~-IeOJCtwL0CmW2OPS3cBzEg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|40px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By P. J. Sikorski, M. Warminski, D. Kubacka, T. Ratajczak, D. Nowis, J. Kowalska, J.Jemielity;<\/span><\/span> Nucleic Acids Research 48, 1607-1626.<\/strong><\/p>\n

[\/et_pb_blurb][et_pb_blurb title=”Azido-Functionalized 5\u02b9-Cap Analogs for Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells” url=”https:\/\/academic.oup.com\/nar\/article\/50\/1\/e3\/6378437?searchresult=1″ url_new_window=”on” image=”https:\/\/onlinelibrary.wiley.com\/cms\/asset\/bb56d256-0937-4f8f-8dcd-e7724957c1ee\/anie201709052-toc-0001-m.jpg” image_icon_width=”100%” content_max_width=”1100px” _builder_version=”4.14.8″ header_font=”|on|||” header_text_color=”#2e2545″ header_line_height=”1.5em” body_text_color=”#8585bd” body_font_size=”16px” body_line_height=”1.9em” background_color=”#ffffff” background_size=”initial” background_position=”top_left” background_repeat=”repeat” image_icon_custom_margin=”0px||||false|false” image_icon_custom_padding=”0px||||false|false” custom_margin=”10%||10%||true|false” custom_padding=”30px|40px|30px|42px||” animation_style=”zoom” animation_direction=”bottom” animation_intensity_zoom=”20%” animation_starting_opacity=”100%” custom_css_blurb_image=”margin-bottom: 0px!important;” box_shadow_style=”preset1″ box_shadow_spread=”-15px” box_shadow_color=”#000000″ locked=”off” global_colors_info=”{}” child_filter_saturate__hover_enabled=”on|hover” title__hover_enabled=”off|desktop”]<\/p>\n

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By<\/span> Mamot A., Sikorski P. J., Warminski M., Kowalska J., Jemielity J;<\/span> Angewandte Chemie International Edition 56, 15628\u201315632<\/strong><\/p>\n

[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.14.8″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2026″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2026<\/h1>\n

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T. Spiewla, K. Czubak, Z. Pilch, M. R. Baranowski, P. S. Krawczyk, K. Affek, W. Antczak, M. Szulc-Gasiorowska, S. Chmielinski, S. Mroczek, M. Brouze, D. Nowis, J. Golab, A. Dziembowski, J. Jemielity, J. Kowalska; PolyA tail segmentation improves the stability of the template DNA and increases the translatability of in vitro<\/em> transcribed mRNA. Nucleic Acids Research<\/em> 54(2), gkaf14<\/strong><\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2025″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2025<\/h1>\n

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K. Gackowska, M. Krejmer-Rabalska, K. Drazkowska, J. Jemielity, E. Krol, B. Szewczyk; Affinity-purified sHBsAg-based virus-like particles as a platform for foreign mRNA binding. Virology<\/em>, 110651<\/strong><\/a><\/span>
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M. Wasinska-Kalwa, A. Mamot, K. Czubak, K. Frankowska, A. A. Rajkiewicz, T. Spiewla, M Warmi\u0144ski, Zofia Pilch, M. Szulc-Gasiorowska, K. Siekan, A. Dziembowski, D. Nowis, J. Golab, J. Kowalska, J.Jemielity; Chemical circularization of in vitro transcribed RNA for exploring circular mRNA design. Nature Communications<\/em> 16, 6455<\/strong>\u00a0<\/span><\/a><\/td>\n<\/tr>\n
S. Chamera, W. Zajko, M. Czarnocki-Cieciura, M. Jaciuk, L. Koziej, J. Nowak, K. Wycisk, M. Sroka, A. Chramiec-Glabik, M. Smietanski, F. Golebiowski, M. Warminski, J. Jemielity, S. Glatt, M. Nowotny; Structural and biochemical characterization of the 3\u2032-5\u2032 tRNA splicing ligases. Journal of Biological Chemistry<\/em> 301(5), 108506<\/strong><\/span><\/a><\/td>\n<\/tr>\n
P. S. Krawczyk, M. Mazur, W. Orzel, O. Gewartowska, S. Jelen, W. Antczak, K. Kasztelan, A. Brouze, K. Matylla-Kulinska, N. Guminska, B. Tarkowski, E. P. Owczarek, K. Affek, P. Turowski, A. Tudek, M. Sroka, T. Spiewla, M. Kusio-Kobia\u0142ka, A. Wesolowska, D. Nowis, J. Golab, J. Kowalska, J. Jemielity, A. Dziembowski, S. Mroczek; Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines. Nature<\/em>\u00a0641, 984\u2013992\u00a0<\/strong><\/span><\/a><\/td>\n<\/tr>\n
T. Spiewla, K. Grab, A. Depaix, K. Ziemkiewicz, M. Warminski, J. Jemielity, J. Kowalska; An MST-based assay reveals new binding preferences of IFIT1 for canonically and noncanonically capped RNAs. RNA<\/em> 31.2 (2025): 181-192<\/strong><\/a>
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H. Bernhard, H. Petr\u017e\u00edlkov\u00e1, B. Popel\u00e1\u0159ov\u00e1, K. Ziemkiewicz, K. Bartosik, M. Warminski, L. Tengo, H. Gr\u00f6ger, L. G. Dolce, C. D. Mackereth, R. Micura, J. Jemielity, E. Kowalinski; Structural basis of Spliced Leader RNA recognition by the Trypanosoma brucei cap-binding complex. Nature Communications<\/em> 16.1 (2025): 685<\/strong><\/a><\/span><\/td>\n<\/tr>\n
M. Chrominski, M. Warminski, M. Kozarski, D. Kubacka, J. Panecka-Hofman, T. Spiewla, M. Zmudzi\u0144ski, J. Jemielity, J. Kowalska; Proximity-induced SuFEx increases the potency of cytosolic nucleotidase inhibitors and reveals a rare example of covalently targeted histidine. RSC Chemical Biology<\/em> 6, 942-947<\/strong><\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”4.14.8″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2024″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2024<\/h1>\n

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K. Grab, M. Fido, T. Spiewla, M. Warminski, J. Jemielity, J. Kowalska; Aptamer-based assay for high-throughput substrate profiling of RNA decapping enzymes. Nucleic Acids Research <\/strong><\/em>gkae919<\/strong>
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M. Warminski, A. Depaix, K. Ziemkiewicz, T. Spiewla, J. Zuberek, K. Drazkowska, H. Kedzierska, A. Popielec, M. R. Baranowski, M. Sklucka, M. Bednarczyk, M. Smietanski, K. Wolosewicz, B. Majewski, R. A. Serwa, D. Nowis, J. Golab, J. Kowalska, J. Jemielity; Trinucleotide cap analogs with triphosphate chain modifications: synthesis, properties, and evaluation as mRNA capping reagents. Nucleic Acids Research<\/em> gkae763<\/strong><\/a><\/span><\/td>\n<\/tr>\n
M. Warminski, K. Grab, K. Szczepanski, T. Spiewla, J. Zuberek, J. Kowalska, J. Jemielity; Photoactivatable mRNA 5\u2032 Cap Analogs for RNA\u2010Protein Crosslinking. Advanced Science<\/em> 2400994<\/strong><\/a><\/span><\/td>\n<\/tr>\n
A. Kozakiewicz-Piekarz, M. Grzeg\u00f3rska, K. Ziemkiewicz, K. Grab, M. R. Baranowski, M. Zapadka, M. Karpiel, B. Kupcewicz, J. Kowalska, M. Wujak; Synthesis, kinetic studies, and QSAR of dinucleoside polyphosphate derivatives as human AK1 inhibitors. Bioorganic Chemistry<\/em> 148, 107432<\/strong><\/a><\/span><\/td>\n<\/tr>\n
B. Benoni, J. F. Potuz\u030cni\u0301k, A. S\u030ckri\u0301ba, R. Benoni, J. Trylcova, M. Tulpa, K. Spustov\u00e1, K. Grab, M. B. Mititelu, J. Pac\u030ces, J. Weber, D. Stanek, J. Kowalska, L. Bednarova, Z. Keckesova, P. Vopalensky, L. Gahurova, H. Cahova; HIV-1 infection reduces NAD capping of host cell snRNA and snoRNA. ACS Chemical Biology<\/em> 19(6), 1243-1249<\/strong><\/a><\/span><\/td>\n<\/tr>\n
M. Warminski, E. Trepkowska, M. Smietanski, P. J. Sikorski, M. R. Baranowski, M. Bednarczyk, H. Kedzierska, B. Majewski, A. Mamot, D. Papiernik, A. Popielec, R. A. Serwa, B. A. Shimanski, P. Sklepkiewicz, M. Sklucka, O. Sokolowska, T. Spiewla, D. Toczydlowska-Socha, Z. Warminska, K. Wolosewicz, J. Zuberek, J. S. Mugridge, D. Nowis, J. Golab, J. Jemielity, J. Kowalska; Trinucleotide mRNA Cap Analogue N 6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo. Journal of the American Chemical Society<\/em> 146(12), 8149-8163<\/strong><\/a><\/span><\/td>\n<\/tr>\n
H. J. Zhang, M. Ociepa, M. Nassir, B. Zheng, S. A. Lewicki, V. Salmaso, H. Baburi, J. Nagel, S. Mirza, B. Bueschbell, H. Al-Hroub, O. Perzanowska, Z. Lin, M. A. Schmidt, M. D. Eastgate, K. A. Jacobson, C. E. M\u00fcller, J. Kowalska, J. Jemielity, P. S. Baran; Stereocontrolled access to thioisosteres of nucleoside di-and triphosphates. Nature Chemistry<\/em> 16(2), 249-258<\/strong><\/a><\/span><\/td>\n<\/tr>\n
P. Surynt, B. A. Wojtczak, M. Chrominski, J. Panecka-Hofman, K. Kwapiszewska, T. Kalwarczyk, D. Kubacka, T. Spiewla, R. Kasprzyk, R. Holyst, J. Kowalska, J. Jemielity; Trimethylguanosine cap-fluorescent molecular rotor (TMG\u2013FMR) conjugates are potent, specific snurportin1 ligands enabling visualization in living cells. Organic & Biomolecular Chemistry<\/em> 22(33), 6763-6790<\/strong><\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2023″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2023<\/h1>\n

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J. Dobrogojski, V. H. Nguyen, J. Kowalska, S. Borek, M. Pietrowska-Borek; The Plasma Membrane Purinoreceptor P2K1\/DORN1 Is Essential in Stomatal Closure Evoked by Extracellular Diadenosine Tetraphosphate (Ap4A) in Arabidopsis thaliana. International Journal of Molecular Sciences<\/em> 24, 16688<\/strong><\/span><\/a><\/td>\n<\/tr>\n
M. Warminski, A. Mamot, A. Depaix, J. Kowalska, J. Jemielity; Chemical Modifications of mRNA Ends for Therapeutic Applications. Accounts of Chemical Research <\/em>56, 2814-2826<\/strong><\/span><\/a><\/td>\n<\/tr>\n
M. Zmudzinski, W. Rut, K. Olech, J. Granda, M. Giurg, M. Burda-Grabowska, R. Kaleta, M. Zgarbova, R. Kasprzyk, L. Zhang, X. Sun, Z. Lv, D. Nayak, M. Kesik-Brodacka, S. K. Olsen, J. Weber, R. Hilgenfeld, J. Jemielity, M. Drag; Ebselen derivatives inhibit SARS-CoV-2 replication by inhibition of its essential proteins: PLpro and Mpro proteases, and nsp14 guanine N7-methyltransferase. Scientific Reports<\/em> 13, 9161<\/strong><\/a><\/span><\/td>\n<\/tr>\n
B. A. Wojtczak, M. Bednarczyk, P. J. Sikorski, A. Wojtczak, P. Surynt, J. Kowalska, J. Jemielity; Synthesis and Evaluation of Diguanosine Cap Analogs Modified at the C8-Position by Suzuki\u2013Miyaura Cross-Coupling: Discovery of 7-Methylguanosine-Based Molecular Rotors. The Journal of Organic Chemistry<\/em> 88, 6827-6846<\/strong><\/a>
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M. Kozarski, K. Drazkowska, M. Bednarczyk, M. Warminski, J. Jemielity, J. Kowalska; Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs. RSC Advances<\/em> 13, 12809-12824<\/strong><\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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2022<\/h1>\n

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A. Pepanian, P. Sommerfeld, R. Kasprzyk, T. Ku\u0308hl, F. A. Binbay, C. Hauser, R. Lo\u0308ser, R. Wodtke, M. Bednarczyk, M. Chrominski, J. Kowalska, J. Jemielity, D. Imhof, M. Pietsch; Fluorescence Anisotropy Assay with Guanine Nucleotides Provides Access to Functional Analysis of G\u03b1i1 Proteins. Analytical Chemistry<\/em> 94, 14410–<\/span><\/strong><\/span><\/span><\/a>14418<\/strong><\/span><\/span><\/a><\/span><\/td>\n<\/tr>\n
K. Drazkowska, R. Tomecki, M. Warminski, N. Baran, D. Cysewski, A. Depaix, R. Kasprzyk, J. Kowalska, J. Jemielity, P. J. Sikorski; 2\u2032-O-Methylation of the second transcribed nucleotide within the mRNA 5\u2032 cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion. Nucleic Acids Research<\/em> 50, 9051-9071<\/strong><\/span><\/span><\/a><\/span><\/td>\n<\/tr>\n
O. Perzanowska, M. Smietanski, J. Jemielity, J. Kowalska; Chemically modified poly (A) analogs targeting PABP: structure activity relationship and translation inhibitory properties. Chemistry\u2013A European Journal<\/em> 28, e202201115<\/strong><\/span><\/span><\/a><\/span><\/td>\n<\/tr>\n
K. Ziemkiewicz, M. Warminski, R. Wojcik, J. Kowalska, J. Jemielity; Quick Access to Nucleobase-Modified Phosphoramidites for the Synthesis of Oligoribonucleotides Containing Post-Transcriptional Modifications and Epitranscriptomic Marks. The Journal of Organic Chemistry<\/em> 87, 10333-10348<\/strong><\/span><\/span><\/a><\/span><\/td>\n<\/tr>\n
M. Chrominski, K. Ziemkiewicz, J. Kowalska, J. Jemielity; Introducing SuFNucs: Sulfamoyl-Fluoride-Functionalized Nucleosides That Undergo Sulfur Fluoride Exchange Reaction. Organic Letters<\/em> 24, 4977-4981<\/strong><\/span><\/span><\/a><\/span><\/td>\n<\/tr>\n
M. Bednarczyk, J. K. Peters, R. Kasprzyk, J. Starek, M. Warminski, T. Spiewla, J. S. Mugridge, J. D. Gross, J. Jemielity, J. Kowalska; Fluorescence-based activity screening assay reveals small molecule inhibitors of vaccinia virus mRNA decapping enzyme D9. ACS Chemical Biology<\/em> 17, 1460-1471<\/strong><\/span><\/span><\/a><\/span><\/td>\n<\/tr>\n
J. K. Peters, R. W. Tibble, M Warminski, J. Jemielity, J. D. Gross; <\/span><\/span>Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis. Structure<\/em> 30, 721-732. e4<\/strong><\/span><\/a><\/span><\/td>\n<\/tr>\n
D. Kubacka, M. Kozarski, M. R. Baranowski, R. Wojcik, J. Panecka-Hofman, D. Strzelecka, J. Basquin, J. Jemielity, J. Kowalska; Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism. Pharmaceuticals<\/em> 15, 554<\/strong><\/a>
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A. Mlynarska-Cieslak, M. Chrominski, T. Spiewla, M. R. Baranowski, M. Bednarczyk, J. Jemielity, J. Kowalska; Fluorinated Phosphoadenosine 5\u2032-Phosphosulfate Analogues for Continuous Sulfotransferase Activity Monitoring and Inhibitor Screening by 19F NMR Spectroscopy. <\/a>ACS Chemical Biology<\/em> 17<\/span>, <\/span>661-669<\/span><\/a>
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A. Mamot, P. J. Sikorski, A. Siekierska, P. de Witte, J. Kowalska, J. Jemielity; Ethylenediamine derivatives efficiently react with oxidized RNA 3\u2032 ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation. Nucleic Acids Research<\/em> 50, e3-e3<\/strong><\/a><\/span><\/td>\n<\/tr>\n
A. Depaix, E. Grudzien-Nogalska, B. Fedorczyk, M. Kiledjian, J. Jemielity, J. Kowalska; Preparation of RNAs with non-canonical 5\u2032 ends using novel di-and trinucleotide reagents for co-transcriptional capping. Frontiers in Molecular Biosciences<\/em> 9, 854170<\/strong><\/a>
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2021<\/h1>\n

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R. Kasprzyk, J. Jemielity; Enzymatic assays to explore viral mRNA capping machinery. <\/a><\/span>ChemBioChem<\/em> 22, 3236-3253<\/span> (Very Important Paper)<\/span><\/a>
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R. Wojcik, M. R. Baranowski, L. Markiewicz, D. Kubacka, M. Bednarczyk, N. Baran, A. Wojtczak, P. J Sikorski, J. Zuberek, J. Kowalska, J. Jemielity; Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5\u2032 cap Analogs: Synthesis and Evaluation as Modulators of Translation. Pharmaceutics<\/em> 13, 1941<\/strong><\/a><\/span><\/td>\n<\/tr>\n
R. Kasprzyk, T. J. Spiewla, M. Smietanski, S. Golojuch, L. Vangeel, S. De Jonghe, D. Jochmans, J. Neyts, J. Kowalska, J. Jemielity; Identification and evaluation of potential SARS-CoV-2 antiviral agents targeting mRNA cap guanine N7-Methyltransferase. Antiviral Research<\/em> 193, 105142<\/strong><\/a><\/span><\/td>\n<\/tr>\n
A. Depaix, A. Mlynarska\u2010Cieslak, M. Warminski, P. J. Sikorski, J. Jemielity, J. Kowalska; RNA Ligation for Mono and Dually Labeled RNAs. Chemistry\u2013A European Journal<\/em> 27, 12190-12197<\/strong><\/a><\/span><\/td>\n<\/tr>\n
O. Perzanowska, M. Majewski, M. Strenkowska, P. G\u0142owala, M. Czarnocki-Cieciura, M. Mazur, J. Kowalska, J. Jemielity; Nucleotide-decorated AuNPs as probes for nucleotide-binding proteins. <\/a><\/span>Scientific Reports<\/em> 11, Art. no. 15741<\/a><\/span>
<\/strong><\/td>\n<\/tr>\n
A. Galloway, A. Kaskar, D. Ditsova, A. Atrih, H. Yoshikawa, C. Gomez-Moreira, O. Suska, M. Warminski, R. Grzela, A. I. Lamond, E. Darzynkiewicz, J. Jemielity, V. H. Cowling; Upregulation of RNA cap methyltransferase RNMT drives ribosome biogenesis during T cell activation. Nucleic Acids Research<\/em> 49, 6722-6738<\/strong><\/a><\/span><\/td>\n<\/tr>\n
R. W. Tibble, A. Depaix, J. Kowalska, J. Jemielity, J. D. Gross; Biomolecular condensates amplify mRNA decapping by biasing enzyme conformation. Nature Chemical Biology<\/em> 17, 615-623<\/strong><\/a><\/span><\/td>\n<\/tr>\n
A. Wojtczak, R. Kasprzyk, M. Warmi\u0144ski, K. Ubych, D. Kubacka, P. J. Sikorski, J. Jemielity, J. Kowalska; Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy.<\/a><\/span> Scientific Reports<\/em> 11, Art, no. 1184<\/a><\/span>
<\/strong><\/td>\n<\/tr>\n
P. Rzymski, L. Borkowski, M. Dr\u0105g, R. Flisiak, J. Jemielity, J. Krajewski, A. Mastalerz-Migas, A. Matyja, K. Pyr\u0107, K. Simon, M. Sutkowski, J. Wysocki, J. Zajkowska, A. Fal; The strategies to support the COVID-19 vaccination with evidence-based communication and tackling misinformation. Vaccines<\/em> 9, Art. no. 109<\/strong><\/a><\/span><\/td>\n<\/tr>\n
M. Warminski, J. Kowalska, E. Nowak, D. Kubacka, R. Tibble, R. Kasprzyk, P. J. Sikorski, J. D. Gross, M. Nowotny, J. Jemielity Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chemical Biology<\/em> 16, 334-343<\/strong><\/a><\/span><\/td>\n<\/tr>\n
N. Kleczewska, P. J. Sikorski, Z. Warminska, L. Markiewicz, R. Kasprzyk, N. Baran, K. Kwapiszewska, A. Karpinska, J. Michalski, R. Holyst, J. Kowalska, J. Jemielity; Cellular delivery of dinucleotides by conjugation with small molecules: Targeting translation initiation for anticancer applications. Chemical Science<\/em> 12, 10242-10251<\/strong><\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2020″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2020<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
D. Strzelecka, M. Smietanski, P. J. Sikorski, M. Warminski, J. Kowalska, J. Jemielity; Phosphodiester modifications in mRNA poly (A) tail prevent deadenylation without compromising protein expression. RNA<\/em> 26 (12), 1815-1837<\/strong><\/td>\n<\/tr>\n
M. R. Baranowski, M. Warminski, J. Jemielity, J. Kowalska; 5\u2032-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR. Nucleic Acids Research<\/em> 48, 8209-8224<\/strong><\/td>\n<\/tr>\n
M. Chrominski, J. Kowalska, J. Jemielity; Efficient Synthesis of Trifluoromethylated Purine Ribonucleosides and Ribonucleotides. Current Protocols in Nucleic Acid Chemistry<\/em> 83, e118<\/strong><\/td>\n<\/tr>\n
M. Warminski, J. Kowalska, J. Jemielity; Solid\u2010Phase Synthesis of RNA 5\u2032\u2010Azides and Their Application for Labeling, Ligation, and Cyclization Via Click Chemistry. Current Protocols in Nucleic Acid Chemistry<\/em> 82, e112<\/strong><\/td>\n<\/tr>\n
R. Kasprzyk, M. Fido, A. Mamot, P. Wanat, M. Smietanski, M. Kopcial, V. H. Cowling, J. Kowalska, J. Jemielity; Direct High\u2010Throughput Screening Assay for mRNA Cap Guanine\u2010N7 Methyltransferase Activity. Chemistry\u2013A European Journal<\/em> 26, 11266-11275<\/strong><\/td>\n<\/tr>\n
S. Golojuch, M. Kopcial, D. Strzelecka, R. Kasprzyk, N. Baran, P. J. Sikorski, , J. Kowalska, J. Jemielity; Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation. Bioorganic & Medicinal Chemistry<\/em> 28, 115523<\/strong><\/td>\n<\/tr>\n
P. J. Sikorski, M. Warminski, D. Kubacka, T. Ratajczak, D. Nowis, J. Kowalska, J. Jemielity; The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5\u2032 cap modulates protein expression in living cells. Nucleic Acids Research<\/em> 48, 1607-1626<\/strong><\/td>\n<\/tr>\n
M. Pietrowska-Borek, A. Wojdy\u0142a-Mamo\u0144, J. Dobrogojski, A. M\u0142ynarska-Cie\u015blak, M. R. Baranowski, J. M. D\u0105browski, J. Kowalska, J. Jemielity, S. Borek, M. Angeles Pedre\u00f1o, A. Guranowski; Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells. Plant Physiology and Biochemistry<\/em> 147, 125-132<\/strong><\/td>\n<\/tr>\n
M. Chrominski, M. R. Baranowski, S. Chmielinski, J. Kowalska, J. Jemielity; Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes. The Journal of Organic Chemistry<\/em> 85, 3440-3453<\/strong><\/td>\n<\/tr>\n
B. Miedziak, A. Dobie\u017cy\u0144ska, Z. M. Dar\u017cynkiewicz, J. Bartkowska, J. Miszkiewicz, J. Kowalska, M. Warminski, M. Tyras, J. Trylska, J. Jemielity, E. Darzynkiewicz, R. Grzela; Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics. RNA<\/em> 26, 58-68<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2019″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2019<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n
R. Kasprzyk, B. J. Starek, S. Ciechanowicz, D. Kubacka, J. Kowalska, J. Jemielity; Fluorescent Turn\u2010On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap\u2010Recognizing Proteins. Chemistry\u2013A European Journal<\/em> 25, 6728-6740<\/strong><\/td>\n<\/tr>\n
M. Kopcial, B. A. Wojtczak, R. Kasprzyk, J. Kowalska, J. Jemielity; N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, reactivity, and applications to the study of cap-binding proteins. Molecules <\/em>24, 1899<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2018″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2018<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n
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B. A. Wojtczak, P. J. Sikorski, K. Fac-D\u0105browska, A. Nowicka, M. Warmi\u0144ski, D. Kubacka, E. Nowak, M. Nowotny, J. Kowalska, J. Jemielity. 5\u2032-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. Journal of the American Chemical Society<\/em> 140, 5987-5999\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Mlynarska-Cie\u015blak A., Depaix A., Grudzien-Nogalska E., Sikorski P.J., Warminski M., Kiledjian M., Jemielity J., Kowalska J. Nicotinamide Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs. Organic Letters<\/em> 20, 7650\u20137655<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Bednarek S., Madan V., Sikorski P.J., Bertenschlager R., Kowalska J., Jemielity J. mRNAs biotinylated within the 5\u2019 cap and protected against decapping: new tools to capture RNA \u2013 protein complexes. Philosophical Transactions of the Royal Society B \u2013 Biological Sciences <\/em>373, <\/em>Article ID:20180167<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Mugridge J.S., Tibble R.W., Ziemniak M., Jemielity J., Gross J.D. Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. Nature Communications<\/em> 9, Art. No.1152<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Walczak S., Sikorski P. J., Kasprzyk R., Kowalska J., Jemielity J. Exploring the potential of phosphotriazole 5\u2032 mRNA cap analogues as efficient translation initiators. Organic and Biomolecular Chemistry<\/em> 16, 6741-6748<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Wanat P., Kasprzyk R., Kopcia\u0142 M., Sikorski P. J., Strzelecka D., Jemielity J., Kowalska J., ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions. Chemical Communications<\/em> 54, 9773-9776<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Essig K., Kronbeck N., Guimaraes J. C., Lohs C., Schlundt A., Hoffmann A., Behrens G., G. Brenner G., Kowalska J., Lopez-Rodriguez C., Jemielity J., Holtmann H., Reiche K., Hackerm\u00fcller J., Sattler M., Zavolan M., Heissmeyer V. Roquin targets mRNAs in a 3\u2032-UTR-specific manner by different modes of regulation. Nature Communications<\/em> 9 Art. No. 3810<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2017″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2017<\/h1>\n

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Mamot A., Sikorski P. J., Warminski M., Kowalska J., Jemielity J.. Azido-Functionalized 5\u02b9-Cap Analogs for Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells. Angewandte Chemie International Edition<\/em> 56, 15628\u201315632<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Rydzik A. M., Warminski M., Sikorski P. J., Baranowski M. R., Walczak S., Kowalska J., Zuberek J., Lukaszewicz M., Nowak E., Claridge T. D. W., Darzynkiewicz E., Nowotny M., Jemielity J..\u00a0 mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Research<\/em> 45, 8661-8675<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Walczak S., Nowicka A., Kubacka D., Fac K., Wanat P., Mroczek S., Kowalska J., Jemielity J.. A novel route for preparing 5\u2032 cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry. Chemical Science<\/em> 8, 260 \u2013 267\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Warminski M., Kowalska J., Jemielity J., Synthesis of RNA 5\u2032-Azides from 2\u2032-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide\u2013Alkyne Cycloaddition Reactions. Organic Letters<\/em> 19,\u00a0 3624\u20133627<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Warminski M., Sikorski P. J., Warminska Z., Lukaszewicz M., Kropiwnicka A., Zuberek J., Darzynkiewicz E., Kowalska J., Jemielity J., Amino-functionalized 5\u2019 cap analogs as tools for site-specific sequence-independent labeling of messenger RNA. Bioconjugate Chemistry<\/em> 28,<\/strong> 1978-1992<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Strzelecka D., Chmielinski S., Bednarek S., Jemielity J., Kowalska J.. Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues. Scientific Reports<\/em> 7\u00a0 Art. No. 8931<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Warminski M., Sikorski P. J., Kowalska J., Jemielity J. . Applications of Phosphate Modification and Labeling to Study (m)RNA Caps. Topics in Current Chemistry<\/em> 375 Art no. 16.<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Min K.-W., Davila S., Zealy R. W., Lloyd L. T., Lee I. Y., Lee R., Roh K. H., Jung A., Jemielity J., Choi E.-J., Yoon J.-H., eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation. Biochimica et Biophysica Acta – Gene Regulatory Mechanisms<\/em> 1860, 761\u2013772<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

B. Kroczynska, G. T. Blyth, R. L. Rafidi, B. Majchrzak-Kita, L. Xu, D. Saleiro, E. M. Kosciuczuk, J. Jemielity, B. Su, J. K. Altman, E. A. Eklund, E. N. Fish, L. C. Platanias. Central Regulatory Role for SIN1 in Interferon \u03b3 (IFN<\/span>\u03b3) Signaling and Generation of Biological Responses. J. Biol. Chem.<\/em> 292, 4743-4752<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”4.14.8″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2016″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2016<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n\n
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Strenkowska M., Grzela R., Majewski M., Wnek K., Kowalska J., Lukaszewicz M., Zuberek J., Darzynkiewicz E., Kuhn A. N., Sahin U., Jemielity J., Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential, Nucleic Acids Researc<\/em>h 44, 9578-9590(IF 10.162)<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Mugridge J. S., Ziemniak M., Jemielity J., Gross J. D., Structural basis of mRNA-cap recognition by Dcp1\u2013Dcp2, Nature Structural & Molecular Biology<\/em> 23, 987\u2013994<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Honcharenko M., Bestas B., Jezowska M., Wojtczak B. A., Moreno P., Romanowska J., B\u00e4chle S.M., Darzynkiewicz E., Jemielity J., Smith C.I.E., Stromberg R., Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognized as a Nuclear Import Signal, RSC Advances<\/em> 6, 51367-51373<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Baranowski M., Nowicka A., Jemielity J., Kowalska J., Fluorescent HTS assay for phosphohydrolases based on nucleoside 5\u02b9-fluorophosphates: application in screening for inhibitors of mRNA Decapping Scavenger and PDE-I, Organic & Biomolecular Chemistry<\/em> 14, 4595-4604<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kasprzyk R., Kowalska J., Wieczorek Z., Szabelski M., Stolarski R., Jemielity J., Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to Decapping Scavenger activity monitoring, Organic & Biomolecular Chemistry<\/em> 14, 3863-3868<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Ziemniak M., Mugridge J.S., Kowalska J., Rhoads R.E., Gross J.D., Jemielity J., Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1\/2 RNA decapping complex, RNA<\/em> 22, 518-529<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Wojtczak B.A., Warminski M., Kowalska J., Lukaszewicz M., Honcharenko M., Smith C. I.E., Stromberg R., Darzynkiewicz E., Jemielity J., Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation, RSC Advances<\/em> 6, 8317-8328<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Kroczynska B., Rafidi R.L., Majchrzak-Kita B., Kosciuczuk E.M., Blyth G.T., Jacek Jemielity J., Warminska Z., Saleiro D., Mehrotra S., Arslan A.D., Fish E.N., Platanias L.C., Interferon \u03b3 (IFN\u03b3)-Signaling via mTORC2 and Regulatory Effects in the Generation of Type II IFN Biological Responses, J. Biol. Chem.<\/em> 291, 2389\u20132396<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2015″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2015<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n
\n

Ziemniak M., Kowalska J., Lukaszewicz M., Zuberek J., Wnek K., Darzynkiewicz E., Jemielity J., Phosphate-modified analogues of m7GTP and m7Gppppm7G \u2013 synthesis and biochemical properties, Bioorganic & Medicinal Chemis<\/em>try 23, 5369\u20135381<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Warminski M., Warminska Z., Kowalska J., Jemielity J., mRNA Cap Modification through Carb\u00adamate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation, European Journal of Organic Chemistry<\/em> 2015, 6153\u20136169\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Wanat P., Walczak S., Wojtczak B. A., Nowakowska M., Jemielity J., Kowalska J., Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC, Organic Letters<\/em> 17, 3062-3065<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Baranowski M. R., Nowicka A., Rydzik A. M., Warminski M., Kasprzyk R., Wojtczak B. A., Wojcik J., Claridge T. D. W., Kowalska J., Jemielity J., Synthesis of Fluorophosphate Nucleotide Analogs and Their Characterization as Tools for 19F NMR Studies, The Journal of Organic Chemistry<\/em> 80, 3982\u20133997<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kijewska K., G\u0142owala P., Kowalska J., Jemielity J., Kaczy\u0144ska K., Janiszewska K., Stolarski J., Blanchard G.J., K\u0119pi\u0144ska D., Lubelska K., Wiktorska K., Pisarek M., Mazur M., Gold-decorated polymer vessel structures as carriers of mRNA cap analogs, Polymer<\/em> 57, 77-87<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kropiwnicka A., Kuchta K., Lukaszewicz M., Kowalska J., Jemielity J., Ginalski K., Darzynkiewicz E., Zuberek J., Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding, Biochemical and Biophysical Research Communications<\/em> 456, 47-52<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2014″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2014<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n
\n

Zochowska M., Piguet A. C., Jemielity J., Kowalska J., Szolajska E., Dufour J. F., Chroboczek J., Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma, Nanomedicine: Nanotechnology, Biology and Medicine<\/em> 11, 67-76<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Zytek M., Kowalska J., Lukaszewicz M., Wojtczak B. A., Zuberek J., Ferenc-Mrozek A., Darzynkiewicz E., Niedzwiecka A., Jemielity J., Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5\u2019,5\u2019-triphosphate bridge, Org. Biomol. Chem.<\/em> 12, 9184 \u2013 9199<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kowalska J., Wypijewska del Nogal A., Darzynkiewicz Z. M., Buck J., Nicola C.,\u00a0 Kuhn A., Lukaszewicz M.,\u00a0Zuberek J.,\u00a0Strenkowska M.,\u00a0Ziemniak M.,\u00a0Maciejczyk M.,\u00a0Bojarska E.,\u00a0Rhoads R. E.,\u00a0Darzynkiewicz E.,\u00a0Sahin U.,\u00a0Jemielity J., Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes, Nucleic Acids Research<\/em> 42, 10245-10264<\/strong> (IF 10.162)<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Nowakowska M., Kowalska J., Martin F., d\u2019Orchymont A., \u017buberek J., \u0141ukaszewicz M., Dar\u017cynkiewicz E., Jemielity J., Cap analogs containing 6-thioguanosine \u2013 reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules, Organic & Biomolecular Chemistry<\/em> 12, 4841-4847<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2013″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2013<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n\n\n
\n

Honcharenko M., Zytek M., Bestas B., Moreno P., Jemielity J., Darzynkiewicz E., Smith C.I. E., Str\u00f6mberg R., Synthesis and evaluation of stability of m3G-CAP analogues in serum-supplemented medium and cytosolic extract, Bioorganic & Medicinal Chemistry<\/em> 21, 7921\u20137928<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Wypijewska del Nogal A., Surleac M. D., Kowalska J., Lukaszewicz M., Jemielity J., Bisaillon M., Darzynkiewicz E., Milac A.L., Bojarska E., Analysis of Decapping Scavenger (DcpS)-cap complex using modified cap analogs reveals molecular determinants for efficient cap binding, FEBS Journal<\/em> 280, 6508\u20136527<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Ziemniak M., Szabelski M., Lukaszewicz M., Nowicka A., Darzynkiewicz E., Wieczorek Z., Rhoads R. E., Jemielity J., Synthesis and evaluation of fluorescent cap analogues for mRNA labeling, RSC Advances<\/em> 3, 20943-20958\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Bretes E., Wojdy\u0142a-Mamo\u0144 A. M., Kowalska J., Jemielity J., Kaczmarek R., Baraniak J., Guranowski A., Hint2, the mitochondrial nucleoside 5\u2032-phosphoramidate hydrolase; properties of the homogeneous protein from sheep (Ovis aries) liver, Acta Biochimica Polonica<\/em> 60, 249-254<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Warminski M., Kowalska J., Buck J., Zuberek J., Lukaszewicz M., Nicola C., Kuhn A. N., Sahin U., Darzynkiewicz E., Jemielity J., The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation, Bioorganic & Medicinal Chemistry Letters<\/em> 23, 3753\u20133758<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kijewska K., Jarz\u0119bi\u0144ska A., Kowalska J., Jemielity J., K\u0119pi\u0144ska D., Szczytko J., Pisarek M., Wiktorska K., Stolarski J., Krysinski P. G., Twardowski A., Mazur M., Magnetic-nanoparticle-decorated polypyrrole microvessels: Toward encapsulation of mRNA cap analogs, Biomacromolecules<\/em> 14, 1867\u22121876<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Ziemniak M., Strenkowska M., Kowalska J., Jemielity J., Potential therapeutic applications of RNA cap analogs, Future Medicinal Chemistry<\/em> 5, 1141-1172<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Dabrowski-Tumanski P., Kowalska J., Jemielity J. ,Efficient and rapid synthesis of nucleoside diphosphate sugars from nucleoside phosphorimidazolides, Eur. J. Org. Chem.<\/em> 2013, 2147 \u2013 2154<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Su W., Slepenkov S. V., Slevin M. K., Lyons S. M., Ziemniak M., Kowalska J., Darzynkiewicz E., Jemielity J., Marzluff W. F., Rhoads R. E., mRNAs containing the histone 3\u2032 stem\u2013loop are degraded primarily by decapping mediated by oligouridylation of the 3\u2032 end, RNA<\/em> 19, 1-16<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2012″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2012<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n
\n

Jemielity J., Lukaszewicz M., Kowalska J., Czarnecki J., Zuberek J., Darzynkiewicz E., Synthesis of biotin labelled cap analogue – incorporable into mRNA transcripts and promoting cap-dependent translation, Org. Biomol. Chem<\/em>.\u00a0 10, 8570-8574<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Strenkowska M., Wanat P., Ziemniak M., Jemielity J., Kowalska J., Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves, Organic Letters<\/em> 14, 4782-4785<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kowalska J., Osowniak A., Zuberek J., Jemielity J., Synthesis of nucleoside phosphosulfates, Bioorganic & Medicinal Chemistry Letters<\/em> 22, 3661-3664<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Szczepaniak S. A., Zuberek J., Darzynkiewicz E., Kufel J., Jemielity J., Affinity resins containing enzymatically resistant mRNA cap analogs-a new tool for the analysis of cap-binding proteins, RNA<\/em> 18, 1421-1432<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Wypijewska A., Bojarska E., Lukaszewicz M., Stepinski J., Jemielity J.,. Davis R.E, Darzynkiewicz E., 7-methylguanosine diphosphate (m7GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity, Biochemistry<\/em> 51, 8003-8013<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Rydzik, A. M., Kulis, M., Lukaszewicz, M., Kowalska, J. , Zuberek, J., Darzynkiewicz, Z. M., Darzynkiewicz, E., Jemielity, J., Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety – fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis, Bioorganic and Medicinal Chemistry<\/em> 20, 1699-1710<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2011″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2011<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n
\n

Su, W., Slepenkov, S., Grudzien-Nogalska, E., Kowalska, J., Kulis, M., Zuberek, J., Lukaszewicz, M., Darzynkiewicz, E., Jemielity, J., Rhoads, R.E. Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH(3), Se, and NH. RNA<\/em> 17, 978-988<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Frank F., Fabian M.R., Stepinski J., Jemielity, J., Darzynkiewicz, E., Sonenberg, N., Nagar B., Structural analysis of 5 ‘-mRNA-cap interactions with the human AGO2 MID domain. EMBO Reports<\/em> 12, 415-420<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Guranowski A.,Wojdyla A.M., Rydzik A.M. , Stepinski J., Jemielity J., Plant nucleoside 5 ‘-phosphoramidate hydrolase; simple purification from yellow lupin (Lupinus luteus) seeds and properties of homogeneous enzyme. Acta<\/strong> <\/em>Biochimica Polonica<\/em> 58, 131-136<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2010″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2010<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n
\n

Kuhn A.N., Diken M., Kreiter S., Selmi A., Kowalska, J. Jemielity, J., Darzynkiewicz, E., Huber, C., Tureci O., Sahin, U. Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo. Gene Therapy<\/em> 17, 961-971<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Jemielity, J. Kowalska, J., Rydzik, A. M., Darzynkiewicz, E., Synthetic mRNA cap analogs with modified triphosphate bridge – synthesis, applications and prospects. New J. Chem.<\/em> 34, 829-844\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Strenkowska M., Kowalska J., Lukaszewicz M., Zuberek J., Su W.,. Rhoads R. E, Darzynkiewicz E., Jemielity J., Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications, New J. Chem.<\/em> 34, 993-1007\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Wypijewska A., Bojarska E., Stepinski, J., Jankowska-Anyszka, M., Jemielity J., Davis, R.E., Darzynkiewicz E. Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies. FEBS J.<\/em> 277, 3003-3013\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Guranowski A, Wojdyla A.M., Zimny J., Wypijewska A., Kowalska J., Jemielity J., Davis, R.E., Bieganowski P. Dual activity of certain HIT-proteins: A. thaliana Hint4 and C-elegans DcpS act on adenosine 5 ‘-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP). FEBS Lett.<\/em> 584, 93-98<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Guranowski A., Wojdyla A.M., Zimny J., Wypijewska A., Kowalska J., Lukaszewicz M., Jemielity J., Darzynkiewicz E., Jagiello A., Bieganowski P. Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins. New J. Chem.<\/em> 34, 888-893<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2009″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2009<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n
\u00a0Kowalska J., Lukaszewicz M., Zuberek J., Darzynkiewicz E., Jemielity J.; Phosphoroselenoate Dinucleotides for Modification of mRNA 5′ End. ChemBioChem<\/em> 10, 2469-2473<\/strong><\/td>\n<\/tr>\n
Rydzik A.M., Lukaszewicz M., Zuberek J., Kowalska J., Darzynkiewicz Z.M., Darzynkiewicz E., Jemielity J.; Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5,5 bridge containing methylenebis(phosphonate) modification Org. Biomol. Chem.<\/em> 7, 4763-4776<\/strong><\/td>\n<\/tr>\n
Zdanowicz A., Thermann R., Kowalska J., Jemielity J., Duncan K., Preiss T., Darzynkiewicz E., Hentze M.W.; Drosophila miR2 Primarily Targets the m7GpppN Cap Structure for Translational Repression. Molec. Cell<\/em> 35, 881-888<\/strong><\/td>\n<\/tr>\n
Kowalska J, Lukaszewicz M, Zuberek J, Ziemniak M, Darzynkiewicz E, Jemielity J.; Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg. Med. Chem. Lett.<\/em> 19, 1921-1925<\/strong><\/td>\n<\/tr>\n
Banerjee H., Palenchar J.B., Lukaszewicz M., Bojarska E., Stepinski J., Jemielity J., Guranowski A., Ng S., Wah D.A., Darzynkiewicz E., Bellofatto V.; Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein\/dinucleoside triphosphatase: Substrate specificity studies on the recombinant and endogenous proteins. RNA<\/em> 15, 1554-1564<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”4.14.8″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2008″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2008<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n
\n

T\u00f6lle M, Jankowski V, Schuchardt M, Wiedon A, Huang T, Hub F, Kowalska J, Jemielity J, Guranowski A, Loddenkemper C, Zidek W, Jankowski J, van der Giet M.Adenosine 5′-Tetraphosphate Is a Highly Potent Purinergic Endothelium-Derived Vasoconstrictor. Circulation Research<\/em> 108, 1100 – 1108<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kowalska J., Lewdorowicz M., Zuberek J., Grudzien-Nogalska E., Bojarska E., Stepinski J., Rhoads R.E., Darzynkiewicz E., Davis R.E., Jemielity J.; Synthesis and Characterization of mRNA Cap Analogs Containing Phosphorothioate Substitutions that Bind Tightly to eIF4E and are Resistant to the Decapping Pyrophosphatase DcpS. RNA<\/em> 14, 1119-1131<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Deshmukh MV, Jones BN, Quang-Dang D-U, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD.; mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2. Molec. Cell<\/em> 29, 324-336<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2007″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2007<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
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Grudzien-Nogalska E, Jemielity J, Kowalska J, Darzynkiewicz E, Rhoads RE.; Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells. RNA 13, 1745-1755<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kowalska J, Lewdorowicz M, Darzynkiewicz E, Jemielity J.; A simple and rapid synthesis of nucleotide analogues containing a phosphorothioate moiety at the terminal position of the phosphate chain. Tetrahedron Lett. 48, 5475-5479<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Grudzien-Nogalska E, Stepinski J, Jemielity J, Zuberek J, Stolarski R, Rhoads RE, Darzynkiewicz E.; Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability. Method Enzymol. 431, 203-227<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Darzynkiewicz ZM, Bojarska E, Kowalska J, Lewdorowicz M, Jemielity J, Kalek M, Stepinski J, Davis RE, Darzynkiewicz E.; Interaction of human decapping scavenger with 5 ‘ mRNA cap analogues: structural requirements for catalytic activity. J Phys-Condens Mat.<\/em> 19 art. no. 285217<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, Darzynkiewicz E.; Weak binding affinity of human 4EHP for mRNA cap analogs. RNA<\/em> 13, 691-697<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kowalska J, Lewdorowicz M, Zuberek J, Bojarska E, Stepinski J, Stolarski R, Darzynkiewicz E, Jemielity J.; Assignment of the absolute configuration of P-chiral 5’mRNA cap analogues containing phosphorothioate moiety. Nucleosides Nucleotides & Nucleic Acids<\/em> 26, 1301-1305<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n

\n

Jemielity J, Stolarski R, Darzynkiewicz E.; Synthesis of H-3 and C-13 labeled mRNA cap dinucleotides-useful tools for NMR, biochemical, and biological studies. Nucleosides Nucleotides & Nucleic Acids 26, 1315-1319<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Lewdorowicz M, Jemielity J, Kierzek R, Shapira M, Stepinski J, Darzynkiewicz E.; Solid-supported synthesis of 5 ‘-mRNA cap-4 from trypanosomatids. Nucleosides Nucleotides & Nucleic Acids 26, 1329-1333<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Wierzchowski J, Pietrzak M, Stepinski J, Jemielity J, Kalek M, Bojarska E, Jankowska-Anyszka M, Davis RE, Darzynkiewicz E.; Kinetics of C elegans DcpS cap hydrolysis studied by fluorescence spectroscopy. Nucleosides Nucleotides & Nucleic Acids 26, 1211-1215<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Lewdorowicz M, Stepinski J, Kierzek R, Jemielity J, Zuberek J, Yoffe Y, Shapira M, Stolarski R, Darzynkiewicz E.; Synthesis of leishmania cap-4 intermediates, cap-2 and cap-3. Nucleosides Nucleotides & Nucleic Acids 26, 1339-1348<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Darzynkiewicz ZM, Bojarska E, Stepinski J, Jemielity J, Jankowska-Anyszka M, Davis RE, Darzynkiewicz E.; Affinity of dinucleotide cap analogues for human decapping scavenger (hdcps). Nucleosides Nucleotides & Nucleic Acids 26, 1349-1352 (2007).<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”4.14.8″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2006″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2006<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n
\n

Kalek M, Jemielity J, Darzynkiewicz ZM, Bojarska E, Stepinski J, Stolarski R, Davis RE, Darzynkiewicz E; Enzymatically Stable 5′ mRNA Cap Analogs: Synthesis and Binding Studies with Human DcpS Decapping Enzyme. Bioorganic and Medicinal Chemistry 14, 3223-3230 (2006).<\/p>\n<\/td>\n<\/tr>\n

\n

Guranowski A, Starzy\u0144ska E, Pietrowska-Borek M, Jemielity J, Kowalska J, Darzynkiewicz E, Thompson MJ, Blackburn MG; Methylene analogues of adenosine-5′-tetraphosphate: their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases. FEBS Journal 273, 829-838<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Grudzien E, Kalek M., Jemielity J, Darzynkiewicz E, Rhoads RE; Differential inhibition of mRNA degradation pathways by novel cap analogs. Journal of Biological Chemistry 281, 1857-186<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2005″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2005<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n\n\n
\n

Westman B, Beeren L, Grudzien E, Stepinski J, Worch R, Zuberek J, Jemielity J, Stolarski R, Darzynkiewicz E, Rhoads RE, Preiss T; The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro. RNA 11, 1505-1513<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kowalska J, Lewdorowicz M, Zuberek J, Bojarska E, Wojcik J, Cohen LS, Davis RE, Stepinski J, Stolarski R, Darzynkiewicz E, Jemielity J; Synthesis of mRNA cap analogues containing phosphorothioate moiety in 5′,5′-triphosphate chain. Nucleosides Nucleotides & Nucleic Acids 24, 595-600<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Jemielity J, Heinonen P, L\u00f6nnberg H, Darzynkiewicz E; Novel approach to solid phase chemical synthesis of oligonucleotide mRNA cap analogues, Nucleosides Nucleotides & Nucleic Acids 24, 601-605<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kalek M, Jemielity J, Zuberek J, Grudzie\u0144 E, Bojarska E, Cohen LS, Stepinski J, Stolarski R, Davis RE, Rhoads RE, Darzynkiewicz E; Synthesis and biochemical properties of novel mRNA 5′ cap analogs resistant to enzymatic hydrolysis. Nucleosides Nucleotides & Nucleic Acids 24, 615-621<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Jemielity J, Pietrowska-Borek M, Starzynska E, Kowalska J, Stolarski R, Guranowski A, Darzynkiewicz E; Synthesis and Enzymatic Characterization of Methylene Analogs of Adenosine 5′-Tetraphosphate (p4A). Nucleosides Nucleotides & Nucleic Acids 24, 589-593 (2005).<\/p>\n<\/td>\n<\/tr>\n

\n

Stepinski J, Zuberek J, Jemielity J, Kalek M, Stolarski R, Darzynkiewicz E; Novel Dinucleoside 5′,5′-Triphosphate Cap Analogues. Synthesis and Affinity for Murine Translation Factor eIF4E. Nucleosides Nucleotides & Nucleic Acids 24, 629-633<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kalek M, Jemielity J, Stepinski J, Stolarski R, Darzynkiewicz E; A Direct Method for the Synthesis of Nucleoside 5′-Methylenebis(phosphonate)s from Nucleosides. Tetrahedron Letters 46, 2417-2421<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2004″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2004<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n
\n

Lewdorowicz M, Yoffe Y, Zuberek J, Jemielity J, Stepinski J, Kierzek R, Stolarski R, Shapira M, Darzynkiewicz E; Chemical synthesis and binding activity of the trypanosomatid cap-4 structure. RNA 10, 1469-1478<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Zuberek J, Jemielity J, Jablonowska A, Stepinski J, Dadlez M, Stolarski R, Darzynkiewicz E; Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5 ‘ terminus. Biochemistry 43, 5370-5379,<\/strong><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_width_px=”710px” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”3.25″ background_position=”top_left” custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_divider color=”#4e5ed0″ divider_weight=”3px” disabled_on=”off|off|off” _builder_version=”3.2″ background_color_gradient_direction=”90deg” max_width=”100px” module_alignment=”center” height=”5px” custom_margin=”||20px|” custom_padding=”||20px|” animation_style=”slide” animation_direction=”bottom” saved_tabs=”all” locked=”off” global_colors_info=”{}”][\/et_pb_divider][et_pb_text admin_label=”Team Section Title” module_id=”2004″ _builder_version=”4.14.8″ header_font=”Montserrat||||” header_text_color=”#1f1f1f” header_font_size=”36px” text_orientation=”center” max_width=”710px” module_alignment=”center” animation_style=”fold” animation_direction=”bottom” animation_intensity_fold=”20%” global_colors_info=”{}”]<\/p>\n

2003<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.14.8″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.14.8″ _module_preset=”default” global_colors_info=”{}”]<\/p>\n\n\n\n\n\n\n\n
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Jemielity J, Fowler T, Zuberek J, Stepinski J, Lewdorowicz M, Niedzwiecka A, Stolarski R, Darzynkiewicz E, Rhoads RE. Novel “anti-reverse” cap analogs with superior translational properties. RNA 9, 1108-1122<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Jemielity J, Stepinski J, Jaremko M, Haber D, Stolarski R, Rhoads RE, Darzynkiewicz E; Synthesis of novel mRNA 5 ‘ cap-analogues: Dinucleoside P-1, P-3-tri-, P-1, P-4-tetra-, and P-1, P-5-pentaphosphates. Nucleosides Nucleotides & Nucleic Acids 22, 691-694<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Zuberek J, Jemielity J, Stepinski J, Lewdorowicz M, Niedzwiecka A, Haber D, Stolarski R, Rhoads RE, Darzynkiewicz E; Binding studies of eukaryotic initiation factor eIF4E with novel mRNA dinucleotide cap analogues. Nucleosides Nucleotides & Nucleic Acids 22, 1703-1706<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Zuberek J, Jemielity J, Niedzwiecka A, Stepinski J, Wyslouch-Cieszynska A, Stolarski R, Darzynkiewicz E; Influence of the length of the phosphate chain in mRNA 5 ‘ cap analogues on their interaction with eukaryotic initiation factor 4E. Nucleosides Nucleotides & Nucleic Acids 22, 1707-1710\u00a0<\/strong><\/p>\n<\/td>\n<\/tr>\n

\n

Kiraga-Motoszko K, Stepinski J, Niedzwiecka A, Jemielity J, Wszelaka-Rylik M, Stolarski R, Zielenkiewicz W, Darzynkiewicz E; Interaction between yeast eukaryotic initiation factor eIF4E and mRNA 5 ‘ cap analogues differs from that for murine eIF4E. Nucleosides Nucleotides & Nucleic Acids 22, 1711-1714<\/strong>\u00a0<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

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