OUR PUBLICATIONS
SELECTED PUBLICATIONS
2024
2023
2022
2021
2020
D. Strzelecka, M. Smietanski, P. J. Sikorski, M. Warminski, J. Kowalska, J. Jemielity; Phosphodiester modifications in mRNA poly (A) tail prevent deadenylation without compromising protein expression. RNA 26 (12), 1815-1837 |
M. R. Baranowski, M. Warminski, J. Jemielity, J. Kowalska; 5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR. Nucleic Acids Research 48, 8209-8224 |
M. Chrominski, J. Kowalska, J. Jemielity; Efficient Synthesis of Trifluoromethylated Purine Ribonucleosides and Ribonucleotides. Current Protocols in Nucleic Acid Chemistry 83, e118 |
M. Warminski, J. Kowalska, J. Jemielity; Solid‐Phase Synthesis of RNA 5′‐Azides and Their Application for Labeling, Ligation, and Cyclization Via Click Chemistry. Current Protocols in Nucleic Acid Chemistry 82, e112 |
R. Kasprzyk, M. Fido, A. Mamot, P. Wanat, M. Smietanski, M. Kopcial, V. H. Cowling, J. Kowalska, J. Jemielity; Direct High‐Throughput Screening Assay for mRNA Cap Guanine‐N7 Methyltransferase Activity. Chemistry–A European Journal 26, 11266-11275 |
S. Golojuch, M. Kopcial, D. Strzelecka, R. Kasprzyk, N. Baran, P. J. Sikorski, , J. Kowalska, J. Jemielity; Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation. Bioorganic & Medicinal Chemistry 28, 115523 |
P. J. Sikorski, M. Warminski, D. Kubacka, T. Ratajczak, D. Nowis, J. Kowalska, J. Jemielity; The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells. Nucleic Acids Research 48, 1607-1626 |
M. Pietrowska-Borek, A. Wojdyła-Mamoń, J. Dobrogojski, A. Młynarska-Cieślak, M. R. Baranowski, J. M. Dąbrowski, J. Kowalska, J. Jemielity, S. Borek, M. Angeles Pedreño, A. Guranowski; Purine and pyrimidine dinucleoside polyphosphates differentially affect the phenylpropanoid pathway in Vitis vinifera L. cv. Monastrell suspension cultured cells. Plant Physiology and Biochemistry 147, 125-132 |
M. Chrominski, M. R. Baranowski, S. Chmielinski, J. Kowalska, J. Jemielity; Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes. The Journal of Organic Chemistry 85, 3440-3453 |
B. Miedziak, A. Dobieżyńska, Z. M. Darżynkiewicz, J. Bartkowska, J. Miszkiewicz, J. Kowalska, M. Warminski, M. Tyras, J. Trylska, J. Jemielity, E. Darzynkiewicz, R. Grzela; Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics. RNA 26, 58-68 |
2019
R. Kasprzyk, B. J. Starek, S. Ciechanowicz, D. Kubacka, J. Kowalska, J. Jemielity; Fluorescent Turn‐On Probes for the Development of Binding and Hydrolytic Activity Assays for mRNA Cap‐Recognizing Proteins. Chemistry–A European Journal 25, 6728-6740 |
M. Kopcial, B. A. Wojtczak, R. Kasprzyk, J. Kowalska, J. Jemielity; N1-Propargylguanosine Modified mRNA Cap Analogs: Synthesis, reactivity, and applications to the study of cap-binding proteins. Molecules 24, 1899 |
2018
B. A. Wojtczak, P. J. Sikorski, K. Fac-Dąbrowska, A. Nowicka, M. Warmiński, D. Kubacka, E. Nowak, M. Nowotny, J. Kowalska, J. Jemielity. 5′-Phosphorothiolate Dinucleotide Cap Analogues: Reagents for Messenger RNA Modification and Potent Small-Molecular Inhibitors of Decapping Enzymes. Journal of the American Chemical Society 140, 5987-5999 |
Mlynarska-Cieślak A., Depaix A., Grudzien-Nogalska E., Sikorski P.J., Warminski M., Kiledjian M., Jemielity J., Kowalska J. Nicotinamide Containing Di- and Trinucleotides as Chemical Tools for Studies of NAD-Capped RNAs. Organic Letters 20, 7650–7655 |
Bednarek S., Madan V., Sikorski P.J., Bertenschlager R., Kowalska J., Jemielity J. mRNAs biotinylated within the 5’ cap and protected against decapping: new tools to capture RNA – protein complexes. Philosophical Transactions of the Royal Society B – Biological Sciences 373, Article ID:20180167 |
Mugridge J.S., Tibble R.W., Ziemniak M., Jemielity J., Gross J.D. Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. Nature Communications 9, Art. No.1152 |
Walczak S., Sikorski P. J., Kasprzyk R., Kowalska J., Jemielity J. Exploring the potential of phosphotriazole 5′ mRNA cap analogues as efficient translation initiators. Organic and Biomolecular Chemistry 16, 6741-6748 |
Wanat P., Kasprzyk R., Kopciał M., Sikorski P. J., Strzelecka D., Jemielity J., Kowalska J., ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions. Chemical Communications 54, 9773-9776 |
Essig K., Kronbeck N., Guimaraes J. C., Lohs C., Schlundt A., Hoffmann A., Behrens G., G. Brenner G., Kowalska J., Lopez-Rodriguez C., Jemielity J., Holtmann H., Reiche K., Hackermüller J., Sattler M., Zavolan M., Heissmeyer V. Roquin targets mRNAs in a 3′-UTR-specific manner by different modes of regulation. Nature Communications 9 Art. No. 3810 |
2017
Mamot A., Sikorski P. J., Warminski M., Kowalska J., Jemielity J.. Azido-Functionalized 5ʹ-Cap Analogs for Preparation of Translationally Active mRNAs Suitable for Fluorescent Labeling in Living Cells. Angewandte Chemie International Edition 56, 15628–15632 |
Rydzik A. M., Warminski M., Sikorski P. J., Baranowski M. R., Walczak S., Kowalska J., Zuberek J., Lukaszewicz M., Nowak E., Claridge T. D. W., Darzynkiewicz E., Nowotny M., Jemielity J.. mRNA cap analogues substituted in the tetraphosphate chain with CX2: identification of O-to-CCl2 as the first bridging modification that confers resistance to decapping without impairing translation. Nucleic Acids Research 45, 8661-8675 |
Walczak S., Nowicka A., Kubacka D., Fac K., Wanat P., Mroczek S., Kowalska J., Jemielity J.. A novel route for preparing 5′ cap mimics and capped RNAs: phosphate-modified cap analogues obtained via click chemistry. Chemical Science 8, 260 – 267 |
Warminski M., Kowalska J., Jemielity J., Synthesis of RNA 5′-Azides from 2′-O-Pivaloyloxymethyl-Protected RNAs and Their Reactivity in Azide–Alkyne Cycloaddition Reactions. Organic Letters 19, 3624–3627 |
Warminski M., Sikorski P. J., Warminska Z., Lukaszewicz M., Kropiwnicka A., Zuberek J., Darzynkiewicz E., Kowalska J., Jemielity J., Amino-functionalized 5’ cap analogs as tools for site-specific sequence-independent labeling of messenger RNA. Bioconjugate Chemistry 28, 1978-1992 |
Strzelecka D., Chmielinski S., Bednarek S., Jemielity J., Kowalska J.. Analysis of mononucleotides by tandem mass spectrometry: investigation of fragmentation pathways for phosphate- and ribose-modified nucleotide analogues. Scientific Reports 7 Art. No. 8931 |
Warminski M., Sikorski P. J., Kowalska J., Jemielity J. . Applications of Phosphate Modification and Labeling to Study (m)RNA Caps. Topics in Current Chemistry 375 Art no. 16. |
Min K.-W., Davila S., Zealy R. W., Lloyd L. T., Lee I. Y., Lee R., Roh K. H., Jung A., Jemielity J., Choi E.-J., Yoon J.-H., eIF4E phosphorylation by MST1 reduces translation of a subset of mRNAs, but increases lncRNA translation. Biochimica et Biophysica Acta – Gene Regulatory Mechanisms 1860, 761–772 |
B. Kroczynska, G. T. Blyth, R. L. Rafidi, B. Majchrzak-Kita, L. Xu, D. Saleiro, E. M. Kosciuczuk, J. Jemielity, B. Su, J. K. Altman, E. A. Eklund, E. N. Fish, L. C. Platanias. Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses. J. Biol. Chem. 292, 4743-4752 |
2016
Strenkowska M., Grzela R., Majewski M., Wnek K., Kowalska J., Lukaszewicz M., Zuberek J., Darzynkiewicz E., Kuhn A. N., Sahin U., Jemielity J., Cap analogs modified with 1,2-dithiodiphosphate moiety protect mRNA from decapping and enhance its translational potential, Nucleic Acids Research 44, 9578-9590(IF 10.162) |
Mugridge J. S., Ziemniak M., Jemielity J., Gross J. D., Structural basis of mRNA-cap recognition by Dcp1–Dcp2, Nature Structural & Molecular Biology 23, 987–994 |
Honcharenko M., Bestas B., Jezowska M., Wojtczak B. A., Moreno P., Romanowska J., Bächle S.M., Darzynkiewicz E., Jemielity J., Smith C.I.E., Stromberg R., Synthetic m3G-CAP attachment necessitates a minimum trinucleotide constituent to be recognized as a Nuclear Import Signal, RSC Advances 6, 51367-51373 |
Baranowski M., Nowicka A., Jemielity J., Kowalska J., Fluorescent HTS assay for phosphohydrolases based on nucleoside 5ʹ-fluorophosphates: application in screening for inhibitors of mRNA Decapping Scavenger and PDE-I, Organic & Biomolecular Chemistry 14, 4595-4604 |
Kasprzyk R., Kowalska J., Wieczorek Z., Szabelski M., Stolarski R., Jemielity J., Acetylpyrene-labelled 7-methylguanine nucleotides: unusual fluorescence properties and application to Decapping Scavenger activity monitoring, Organic & Biomolecular Chemistry 14, 3863-3868 |
Ziemniak M., Mugridge J.S., Kowalska J., Rhoads R.E., Gross J.D., Jemielity J., Two-headed tetraphosphate cap analogs are inhibitors of the Dcp1/2 RNA decapping complex, RNA 22, 518-529 |
Wojtczak B.A., Warminski M., Kowalska J., Lukaszewicz M., Honcharenko M., Smith C. I.E., Stromberg R., Darzynkiewicz E., Jemielity J., Clickable trimethylguanosine cap analogs modified within the triphosphate bridge: synthesis, conjugation to RNA and susceptibility to degradation, RSC Advances 6, 8317-8328 |
Kroczynska B., Rafidi R.L., Majchrzak-Kita B., Kosciuczuk E.M., Blyth G.T., Jacek Jemielity J., Warminska Z., Saleiro D., Mehrotra S., Arslan A.D., Fish E.N., Platanias L.C., Interferon γ (IFNγ)-Signaling via mTORC2 and Regulatory Effects in the Generation of Type II IFN Biological Responses, J. Biol. Chem. 291, 2389–2396 |
2015
Ziemniak M., Kowalska J., Lukaszewicz M., Zuberek J., Wnek K., Darzynkiewicz E., Jemielity J., Phosphate-modified analogues of m7GTP and m7Gppppm7G – synthesis and biochemical properties, Bioorganic & Medicinal Chemistry 23, 5369–5381 |
Warminski M., Warminska Z., Kowalska J., Jemielity J., mRNA Cap Modification through Carbamate Chemistry: Synthesis of Amino- and Carboxy-Functionalised Cap Analogues Suitable for Labelling and Bioconjugation, European Journal of Organic Chemistry 2015, 6153–6169 |
Wanat P., Walczak S., Wojtczak B. A., Nowakowska M., Jemielity J., Kowalska J., Ethynyl, 2-Propynyl, and 3-Butynyl C-Phosphonate Analogues of Nucleoside Di- and Triphosphates: Synthesis and Reactivity in CuAAC, Organic Letters 17, 3062-3065 |
Baranowski M. R., Nowicka A., Rydzik A. M., Warminski M., Kasprzyk R., Wojtczak B. A., Wojcik J., Claridge T. D. W., Kowalska J., Jemielity J., Synthesis of Fluorophosphate Nucleotide Analogs and Their Characterization as Tools for 19F NMR Studies, The Journal of Organic Chemistry 80, 3982–3997 |
Kijewska K., Głowala P., Kowalska J., Jemielity J., Kaczyńska K., Janiszewska K., Stolarski J., Blanchard G.J., Kępińska D., Lubelska K., Wiktorska K., Pisarek M., Mazur M., Gold-decorated polymer vessel structures as carriers of mRNA cap analogs, Polymer 57, 77-87 |
Kropiwnicka A., Kuchta K., Lukaszewicz M., Kowalska J., Jemielity J., Ginalski K., Darzynkiewicz E., Zuberek J., Five eIF4E isoforms from Arabidopsis thaliana are characterized by distinct features of cap analogs binding, Biochemical and Biophysical Research Communications 456, 47-52 |
2014
Zochowska M., Piguet A. C., Jemielity J., Kowalska J., Szolajska E., Dufour J. F., Chroboczek J., Virus-like particle-mediated intracellular delivery of mRNA cap analog with in vivo activity against hepatocellular carcinoma, Nanomedicine: Nanotechnology, Biology and Medicine 11, 67-76 |
Zytek M., Kowalska J., Lukaszewicz M., Wojtczak B. A., Zuberek J., Ferenc-Mrozek A., Darzynkiewicz E., Niedzwiecka A., Jemielity J., Towards novel efficient and stable nuclear import signals: synthesis and properties of trimethylguanosine cap analogs modified within the 5’,5’-triphosphate bridge, Org. Biomol. Chem. 12, 9184 – 9199 |
Kowalska J., Wypijewska del Nogal A., Darzynkiewicz Z. M., Buck J., Nicola C., Kuhn A., Lukaszewicz M., Zuberek J., Strenkowska M., Ziemniak M., Maciejczyk M., Bojarska E., Rhoads R. E., Darzynkiewicz E., Sahin U., Jemielity J., Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes, Nucleic Acids Research 42, 10245-10264 (IF 10.162) |
Nowakowska M., Kowalska J., Martin F., d’Orchymont A., Żuberek J., Łukaszewicz M., Darżynkiewicz E., Jemielity J., Cap analogs containing 6-thioguanosine – reagents for the synthesis of mRNAs selectively photo-crosslinkable with cap-binding biomolecules, Organic & Biomolecular Chemistry 12, 4841-4847 |
2013
Honcharenko M., Zytek M., Bestas B., Moreno P., Jemielity J., Darzynkiewicz E., Smith C.I. E., Strömberg R., Synthesis and evaluation of stability of m3G-CAP analogues in serum-supplemented medium and cytosolic extract, Bioorganic & Medicinal Chemistry 21, 7921–7928 |
Wypijewska del Nogal A., Surleac M. D., Kowalska J., Lukaszewicz M., Jemielity J., Bisaillon M., Darzynkiewicz E., Milac A.L., Bojarska E., Analysis of Decapping Scavenger (DcpS)-cap complex using modified cap analogs reveals molecular determinants for efficient cap binding, FEBS Journal 280, 6508–6527 |
Ziemniak M., Szabelski M., Lukaszewicz M., Nowicka A., Darzynkiewicz E., Wieczorek Z., Rhoads R. E., Jemielity J., Synthesis and evaluation of fluorescent cap analogues for mRNA labeling, RSC Advances 3, 20943-20958 |
Bretes E., Wojdyła-Mamoń A. M., Kowalska J., Jemielity J., Kaczmarek R., Baraniak J., Guranowski A., Hint2, the mitochondrial nucleoside 5′-phosphoramidate hydrolase; properties of the homogeneous protein from sheep (Ovis aries) liver, Acta Biochimica Polonica 60, 249-254 |
Warminski M., Kowalska J., Buck J., Zuberek J., Lukaszewicz M., Nicola C., Kuhn A. N., Sahin U., Darzynkiewicz E., Jemielity J., The synthesis of isopropylidene mRNA cap analogs modified with phosphorothioate moiety and their evaluation as promoters of mRNA translation, Bioorganic & Medicinal Chemistry Letters 23, 3753–3758 |
Kijewska K., Jarzębińska A., Kowalska J., Jemielity J., Kępińska D., Szczytko J., Pisarek M., Wiktorska K., Stolarski J., Krysinski P. G., Twardowski A., Mazur M., Magnetic-nanoparticle-decorated polypyrrole microvessels: Toward encapsulation of mRNA cap analogs, Biomacromolecules 14, 1867−1876 |
Ziemniak M., Strenkowska M., Kowalska J., Jemielity J., Potential therapeutic applications of RNA cap analogs, Future Medicinal Chemistry 5, 1141-1172 |
Dabrowski-Tumanski P., Kowalska J., Jemielity J. ,Efficient and rapid synthesis of nucleoside diphosphate sugars from nucleoside phosphorimidazolides, Eur. J. Org. Chem. 2013, 2147 – 2154 |
Su W., Slepenkov S. V., Slevin M. K., Lyons S. M., Ziemniak M., Kowalska J., Darzynkiewicz E., Jemielity J., Marzluff W. F., Rhoads R. E., mRNAs containing the histone 3′ stem–loop are degraded primarily by decapping mediated by oligouridylation of the 3′ end, RNA 19, 1-16 |
2012
Jemielity J., Lukaszewicz M., Kowalska J., Czarnecki J., Zuberek J., Darzynkiewicz E., Synthesis of biotin labelled cap analogue – incorporable into mRNA transcripts and promoting cap-dependent translation, Org. Biomol. Chem. 10, 8570-8574 |
Strenkowska M., Wanat P., Ziemniak M., Jemielity J., Kowalska J., Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves, Organic Letters 14, 4782-4785 |
Kowalska J., Osowniak A., Zuberek J., Jemielity J., Synthesis of nucleoside phosphosulfates, Bioorganic & Medicinal Chemistry Letters 22, 3661-3664 |
Szczepaniak S. A., Zuberek J., Darzynkiewicz E., Kufel J., Jemielity J., Affinity resins containing enzymatically resistant mRNA cap analogs-a new tool for the analysis of cap-binding proteins, RNA 18, 1421-1432 |
Wypijewska A., Bojarska E., Lukaszewicz M., Stepinski J., Jemielity J.,. Davis R.E, Darzynkiewicz E., 7-methylguanosine diphosphate (m7GDP) is not hydrolyzed but strongly bound by decapping scavenger (DcpS) enzymes and potently inhibits their activity, Biochemistry 51, 8003-8013 |
Rydzik, A. M., Kulis, M., Lukaszewicz, M., Kowalska, J. , Zuberek, J., Darzynkiewicz, Z. M., Darzynkiewicz, E., Jemielity, J., Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety – fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis, Bioorganic and Medicinal Chemistry 20, 1699-1710 |
2011
Su, W., Slepenkov, S., Grudzien-Nogalska, E., Kowalska, J., Kulis, M., Zuberek, J., Lukaszewicz, M., Darzynkiewicz, E., Jemielity, J., Rhoads, R.E. Translation, stability, and resistance to decapping of mRNAs containing caps substituted in the triphosphate chain with BH(3), Se, and NH. RNA 17, 978-988 |
Frank F., Fabian M.R., Stepinski J., Jemielity, J., Darzynkiewicz, E., Sonenberg, N., Nagar B., Structural analysis of 5 ‘-mRNA-cap interactions with the human AGO2 MID domain. EMBO Reports 12, 415-420 |
Guranowski A.,Wojdyla A.M., Rydzik A.M. , Stepinski J., Jemielity J., Plant nucleoside 5 ‘-phosphoramidate hydrolase; simple purification from yellow lupin (Lupinus luteus) seeds and properties of homogeneous enzyme. Acta Biochimica Polonica 58, 131-136 |
2010
Kuhn A.N., Diken M., Kreiter S., Selmi A., Kowalska, J. Jemielity, J., Darzynkiewicz, E., Huber, C., Tureci O., Sahin, U. Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo. Gene Therapy 17, 961-971 |
Jemielity, J. Kowalska, J., Rydzik, A. M., Darzynkiewicz, E., Synthetic mRNA cap analogs with modified triphosphate bridge – synthesis, applications and prospects. New J. Chem. 34, 829-844 |
Strenkowska M., Kowalska J., Lukaszewicz M., Zuberek J., Su W.,. Rhoads R. E, Darzynkiewicz E., Jemielity J., Towards mRNA with superior translational activity: synthesis and properties of ARCA tetraphosphates with single phosphorothioate modifications, New J. Chem. 34, 993-1007 |
Wypijewska A., Bojarska E., Stepinski, J., Jankowska-Anyszka, M., Jemielity J., Davis, R.E., Darzynkiewicz E. Structural requirements for Caenorhabditis elegans DcpS substrates based on fluorescence and HPLC enzyme kinetic studies. FEBS J. 277, 3003-3013 |
Guranowski A, Wojdyla A.M., Zimny J., Wypijewska A., Kowalska J., Jemielity J., Davis, R.E., Bieganowski P. Dual activity of certain HIT-proteins: A. thaliana Hint4 and C-elegans DcpS act on adenosine 5 ‘-phosphosulfate as hydrolases (forming AMP) and as phosphorylases (forming ADP). FEBS Lett. 584, 93-98 |
Guranowski A., Wojdyla A.M., Zimny J., Wypijewska A., Kowalska J., Lukaszewicz M., Jemielity J., Darzynkiewicz E., Jagiello A., Bieganowski P. Recognition of different nucleotidyl-derivatives as substrates of reactions catalyzed by various HIT-proteins. New J. Chem. 34, 888-893 |
2009
Kowalska J., Lukaszewicz M., Zuberek J., Darzynkiewicz E., Jemielity J.; Phosphoroselenoate Dinucleotides for Modification of mRNA 5′ End. ChemBioChem 10, 2469-2473 |
Rydzik A.M., Lukaszewicz M., Zuberek J., Kowalska J., Darzynkiewicz Z.M., Darzynkiewicz E., Jemielity J.; Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5,5 bridge containing methylenebis(phosphonate) modification Org. Biomol. Chem. 7, 4763-4776 |
Zdanowicz A., Thermann R., Kowalska J., Jemielity J., Duncan K., Preiss T., Darzynkiewicz E., Hentze M.W.; Drosophila miR2 Primarily Targets the m7GpppN Cap Structure for Translational Repression. Molec. Cell 35, 881-888 |
Kowalska J, Lukaszewicz M, Zuberek J, Ziemniak M, Darzynkiewicz E, Jemielity J.; Phosphorothioate analogs of m7GTP are enzymatically stable inhibitors of cap-dependent translation. Bioorg. Med. Chem. Lett. 19, 1921-1925 |
Banerjee H., Palenchar J.B., Lukaszewicz M., Bojarska E., Stepinski J., Jemielity J., Guranowski A., Ng S., Wah D.A., Darzynkiewicz E., Bellofatto V.; Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: Substrate specificity studies on the recombinant and endogenous proteins. RNA 15, 1554-1564 |
2008
Tölle M, Jankowski V, Schuchardt M, Wiedon A, Huang T, Hub F, Kowalska J, Jemielity J, Guranowski A, Loddenkemper C, Zidek W, Jankowski J, van der Giet M.Adenosine 5′-Tetraphosphate Is a Highly Potent Purinergic Endothelium-Derived Vasoconstrictor. Circulation Research 108, 1100 – 1108 |
Kowalska J., Lewdorowicz M., Zuberek J., Grudzien-Nogalska E., Bojarska E., Stepinski J., Rhoads R.E., Darzynkiewicz E., Davis R.E., Jemielity J.; Synthesis and Characterization of mRNA Cap Analogs Containing Phosphorothioate Substitutions that Bind Tightly to eIF4E and are Resistant to the Decapping Pyrophosphatase DcpS. RNA 14, 1119-1131 |
Deshmukh MV, Jones BN, Quang-Dang D-U, Flinders J, Floor SN, Kim C, Jemielity J, Kalek M, Darzynkiewicz E, Gross JD.; mRNA Decapping Is Promoted by an RNA-Binding Channel in Dcp2. Molec. Cell 29, 324-336 |
2007
Grudzien-Nogalska E, Jemielity J, Kowalska J, Darzynkiewicz E, Rhoads RE.; Phosphorothioate cap analogs stabilize mRNA and increase translational efficiency in mammalian cells. RNA 13, 1745-1755 |
Kowalska J, Lewdorowicz M, Darzynkiewicz E, Jemielity J.; A simple and rapid synthesis of nucleotide analogues containing a phosphorothioate moiety at the terminal position of the phosphate chain. Tetrahedron Lett. 48, 5475-5479 |
Grudzien-Nogalska E, Stepinski J, Jemielity J, Zuberek J, Stolarski R, Rhoads RE, Darzynkiewicz E.; Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability. Method Enzymol. 431, 203-227 |
Darzynkiewicz ZM, Bojarska E, Kowalska J, Lewdorowicz M, Jemielity J, Kalek M, Stepinski J, Davis RE, Darzynkiewicz E.; Interaction of human decapping scavenger with 5 ‘ mRNA cap analogues: structural requirements for catalytic activity. J Phys-Condens Mat. 19 art. no. 285217 |
Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, Darzynkiewicz E.; Weak binding affinity of human 4EHP for mRNA cap analogs. RNA 13, 691-697 |
Kowalska J, Lewdorowicz M, Zuberek J, Bojarska E, Stepinski J, Stolarski R, Darzynkiewicz E, Jemielity J.; Assignment of the absolute configuration of P-chiral 5’mRNA cap analogues containing phosphorothioate moiety. Nucleosides Nucleotides & Nucleic Acids 26, 1301-1305 |
Jemielity J, Stolarski R, Darzynkiewicz E.; Synthesis of H-3 and C-13 labeled mRNA cap dinucleotides-useful tools for NMR, biochemical, and biological studies. Nucleosides Nucleotides & Nucleic Acids 26, 1315-1319 |
Lewdorowicz M, Jemielity J, Kierzek R, Shapira M, Stepinski J, Darzynkiewicz E.; Solid-supported synthesis of 5 ‘-mRNA cap-4 from trypanosomatids. Nucleosides Nucleotides & Nucleic Acids 26, 1329-1333 |
Wierzchowski J, Pietrzak M, Stepinski J, Jemielity J, Kalek M, Bojarska E, Jankowska-Anyszka M, Davis RE, Darzynkiewicz E.; Kinetics of C elegans DcpS cap hydrolysis studied by fluorescence spectroscopy. Nucleosides Nucleotides & Nucleic Acids 26, 1211-1215 |
Lewdorowicz M, Stepinski J, Kierzek R, Jemielity J, Zuberek J, Yoffe Y, Shapira M, Stolarski R, Darzynkiewicz E.; Synthesis of leishmania cap-4 intermediates, cap-2 and cap-3. Nucleosides Nucleotides & Nucleic Acids 26, 1339-1348 |
Darzynkiewicz ZM, Bojarska E, Stepinski J, Jemielity J, Jankowska-Anyszka M, Davis RE, Darzynkiewicz E.; Affinity of dinucleotide cap analogues for human decapping scavenger (hdcps). Nucleosides Nucleotides & Nucleic Acids 26, 1349-1352 (2007). |
2006
Kalek M, Jemielity J, Darzynkiewicz ZM, Bojarska E, Stepinski J, Stolarski R, Davis RE, Darzynkiewicz E; Enzymatically Stable 5′ mRNA Cap Analogs: Synthesis and Binding Studies with Human DcpS Decapping Enzyme. Bioorganic and Medicinal Chemistry 14, 3223-3230 (2006). |
Guranowski A, Starzyńska E, Pietrowska-Borek M, Jemielity J, Kowalska J, Darzynkiewicz E, Thompson MJ, Blackburn MG; Methylene analogues of adenosine-5′-tetraphosphate: their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases. FEBS Journal 273, 829-838 |
Grudzien E, Kalek M., Jemielity J, Darzynkiewicz E, Rhoads RE; Differential inhibition of mRNA degradation pathways by novel cap analogs. Journal of Biological Chemistry 281, 1857-186 |
2005
Westman B, Beeren L, Grudzien E, Stepinski J, Worch R, Zuberek J, Jemielity J, Stolarski R, Darzynkiewicz E, Rhoads RE, Preiss T; The antiviral drug ribavirin does not mimic the 7-methylguanosine moiety of the mRNA cap structure in vitro. RNA 11, 1505-1513 |
Kowalska J, Lewdorowicz M, Zuberek J, Bojarska E, Wojcik J, Cohen LS, Davis RE, Stepinski J, Stolarski R, Darzynkiewicz E, Jemielity J; Synthesis of mRNA cap analogues containing phosphorothioate moiety in 5′,5′-triphosphate chain. Nucleosides Nucleotides & Nucleic Acids 24, 595-600 |
Jemielity J, Heinonen P, Lönnberg H, Darzynkiewicz E; Novel approach to solid phase chemical synthesis of oligonucleotide mRNA cap analogues, Nucleosides Nucleotides & Nucleic Acids 24, 601-605 |
Kalek M, Jemielity J, Zuberek J, Grudzień E, Bojarska E, Cohen LS, Stepinski J, Stolarski R, Davis RE, Rhoads RE, Darzynkiewicz E; Synthesis and biochemical properties of novel mRNA 5′ cap analogs resistant to enzymatic hydrolysis. Nucleosides Nucleotides & Nucleic Acids 24, 615-621 |
Jemielity J, Pietrowska-Borek M, Starzynska E, Kowalska J, Stolarski R, Guranowski A, Darzynkiewicz E; Synthesis and Enzymatic Characterization of Methylene Analogs of Adenosine 5′-Tetraphosphate (p4A). Nucleosides Nucleotides & Nucleic Acids 24, 589-593 (2005). |
Stepinski J, Zuberek J, Jemielity J, Kalek M, Stolarski R, Darzynkiewicz E; Novel Dinucleoside 5′,5′-Triphosphate Cap Analogues. Synthesis and Affinity for Murine Translation Factor eIF4E. Nucleosides Nucleotides & Nucleic Acids 24, 629-633 |
Kalek M, Jemielity J, Stepinski J, Stolarski R, Darzynkiewicz E; A Direct Method for the Synthesis of Nucleoside 5′-Methylenebis(phosphonate)s from Nucleosides. Tetrahedron Letters 46, 2417-2421 |
2004
Lewdorowicz M, Yoffe Y, Zuberek J, Jemielity J, Stepinski J, Kierzek R, Stolarski R, Shapira M, Darzynkiewicz E; Chemical synthesis and binding activity of the trypanosomatid cap-4 structure. RNA 10, 1469-1478 |
Zuberek J, Jemielity J, Jablonowska A, Stepinski J, Dadlez M, Stolarski R, Darzynkiewicz E; Influence of electric charge variation at residues 209 and 159 on the interaction of eIF4E with the mRNA 5 ‘ terminus. Biochemistry 43, 5370-5379, |
2003
Jemielity J, Fowler T, Zuberek J, Stepinski J, Lewdorowicz M, Niedzwiecka A, Stolarski R, Darzynkiewicz E, Rhoads RE. Novel “anti-reverse” cap analogs with superior translational properties. RNA 9, 1108-1122 |
Jemielity J, Stepinski J, Jaremko M, Haber D, Stolarski R, Rhoads RE, Darzynkiewicz E; Synthesis of novel mRNA 5 ‘ cap-analogues: Dinucleoside P-1, P-3-tri-, P-1, P-4-tetra-, and P-1, P-5-pentaphosphates. Nucleosides Nucleotides & Nucleic Acids 22, 691-694 |
Zuberek J, Jemielity J, Stepinski J, Lewdorowicz M, Niedzwiecka A, Haber D, Stolarski R, Rhoads RE, Darzynkiewicz E; Binding studies of eukaryotic initiation factor eIF4E with novel mRNA dinucleotide cap analogues. Nucleosides Nucleotides & Nucleic Acids 22, 1703-1706 |
Zuberek J, Jemielity J, Niedzwiecka A, Stepinski J, Wyslouch-Cieszynska A, Stolarski R, Darzynkiewicz E; Influence of the length of the phosphate chain in mRNA 5 ‘ cap analogues on their interaction with eukaryotic initiation factor 4E. Nucleosides Nucleotides & Nucleic Acids 22, 1707-1710 |
Kiraga-Motoszko K, Stepinski J, Niedzwiecka A, Jemielity J, Wszelaka-Rylik M, Stolarski R, Zielenkiewicz W, Darzynkiewicz E; Interaction between yeast eukaryotic initiation factor eIF4E and mRNA 5 ‘ cap analogues differs from that for murine eIF4E. Nucleosides Nucleotides & Nucleic Acids 22, 1711-1714 |